摘要
Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPs-based nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
Gold-based nano materials with plasmonic properties exhibit various potentials for biomedical applications.In this work,gold nanoprisms(GNPs)was synthesized and then modified with LyP-1,a tumo r-homing peptide,to imp rove the affinity of the GNPs to tumor cells,thus,to imp rove the efficacy of tumor-targe ted photothermal therapy.The introduction of NIR dye IR780 not only enabled the GNPsbased nanosystem with the surface-enhanced resonant Raman scattering(SERRS)property,but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation.The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo,which resulted in enhanced tumor-targe ting photothermal therapeutic efficacy after laser irradiation.Hence,the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
基金
financially supported by the Application Fundamental Research Foundation of Sichuan Province Science and Technology Department, China (No. 2016JY0157)
the State Sponsored Scholarship for Visiting Scholar from China Scholarship Council, the Outstanding Science and Technology Projects for Returned Overseas Chinese Scholars, Sichuan Province, China, theNational Natural Science Foundation of China (No. 31600811)
the National Training Program of Innovation and Entrepreneurship for Undergraduates(No. 201813705025)
