Graves病^131I治疗的预后因素分析

Analysis of prognosis factors on radioactive ^131I treatment of Graves' disease

Graves病是甲状腺毒症最常见的病因。目前^131I治疗在Graves病的治疗中应用广泛,但^131I治疗也可能会失败或引发甲状腺功能减退,因此,研究^131I治疗的预后因素具有极大的临床价值。患者的年龄、性别、病程、血清学指标、^131I治疗剂量、甲状腺体积和质量、^131I的有效半衰期、甲状腺的摄锝率和摄碘率、^131I转换率等多项指标均可能对^131I的治疗效果有所影响,其中部分指标尚存争议。笔者就^131I治疗的预后因素进行系统地归纳总结,以期为临床医师的决策提供帮助。

Graves' disease is the most common etiology of thyrotoxicosis.^131I therapy is widely used to treat Graves' disease but may fail or course hypothyroidism. Thus, the study of prognostic factors of Graves' disease is of great clinical value. Research suggests that several factors, including the patient' s age, gender, course, serological indices,^131I therapy dose, thyroid volume and weight, effective half-life of ^131I, technetium-99m pertechnetate thyroid uptake rate, radioactive iodine uptake rate, and thyroidal ^131I turnover rate, may have important impacts on the results of ^131I therapy;indeed, some of them remain controversial. The aim of this paper is to summarize the prognostic factors of ^131I treatment to help clinicians decide on the best treatment route.