血清趋化因子CXCL13水平与支气管哮喘的相关性研究

Correlation of serum chemokine CXCL13 levels with bronchial asthma

目的探讨血清C-X-C趋化因子13(CXCL13)水平与支气管哮喘不同疾病状态的相关性及其临床意义。方法选取2015年1月至2016年4月安徽医科大学第一附属医院干部呼吸与危重症科诊断为支气管哮喘急性发作期患者32例(急性发作期组),慢性持续期患者31例(慢性持续期组)为研究对象,并选取19例同期健康体检者为正常对照组纳入研究,检测3组研究对象血清CXCL13、免疫球蛋白E(IgE)、白细胞介素4(IL-4)、外周血嗜酸性粒细胞百分比(EOS%),并比较其CXCL13的差异,分析急性发作期患者CXCL13、IgE、IL-4、EOS%之间的相关性;检测3组研究对象肺功能[用力肺活量占预计值百分比(FVC%)、第一秒用力呼气量占预计值百分比(FEV1%)、第一秒用力呼气量/用力肺活量(FEV1/FVC)],分析急性发作期患者CXCL13水平与FVC%、FEV1%、FEV1/FVC之间的相关性。结果支气管哮喘急性发作期组CXCL13、IgE、IL-4、EOS%水平高于慢性持续期组和正常对照组,差异均有统计学意义(P<0.05);支气管哮喘急性发作期组血清CXCL13与IgE、IL-4及EOS%呈正相关(r=0.507、0.334、0.586,P<0.05),与FEV1%呈负相关(r=-0.389,P<0.05)。结论血清CXCL13可能在支气管哮喘的进程中发挥促炎作用。

Objective To investigate the changes of serum chemokine CXCL13 levels in patients with bronchial asthma and its siganificance in asthma. Methods 32 cases of acute attack of bronchial asthma,31 cases of chronic persistent period from outpatient department and department of Geriatric Pulmonary and Critical Care, the First Affiliated Hospital of Anhui Medical University and 19 healthy persons in the same period as the normal control group were selected.and tested for serum CXCL13, IgE, IL-4, peripheral Eosinophil (EOS) count and lung function test(FVC%,FEVI%,FEVI/FVC), and the data were analyzed. Results The levels of CXCL13, IgE, IL-4 and EOS% in acute episode of bronchial asthma were significantly higher than those in the chronic duration group and the normal control group ( P < 0.05). There was a positive correlation between the level of serum CXCL13 and IgE, IL-4, in the patients with acute attack of bronchial asthma ( r =0.507、0.334、 0.586 , P <0.05), and a negative correlation between the level of serum CXCL13 and FEV1%( r =-0.389 , P <0.05). Conclusion Serum CXCL/3 may play an inflammatory role in the development of bronchial asthma.