吉西他滨热化疗灌注联合TACE对肝癌患者疗效及肿瘤细胞因子水平的影响

Effect of Gemcitabine Combined with Thermochemotherapy and Perfusion with TACE on the Efficacy and Tumor Cytokine Levels in Patients with Liver Cancer

目的探讨吉西他滨热化疗灌注联合TACE对肝癌患者疗效及肿瘤细胞因子水平的影响。方法选取2017年1月至2018年1月在大连市友谊医院就诊的80例肝癌随机分为试验组额对照组,对照组40例采取吉西他滨热化疗灌,试验组40例使用吉西他滨热化疗灌注联合TACE治疗,比较两组患者治疗后的疗效及肿瘤细胞因子水平。结果试验组有效利率高于对照组,差异有统计学意义(P<0.05);试验组VEGF、sIL-2R、HIF-2α值均优于对照组,差异有统计学意义(P<0.05)。结论对肝癌患者使用吉西他滨热化疗灌注联合TACE可以明显提高肝癌患者的有效率和降低肿瘤因子水平,值得在临床推广。

Objective To study the gemcitabine hot perfusion chemotherapy combined with conventional curative effect and tumor cell factor levels in patients with liver cancer. Methods From January 2017 to January 2018 in dalian friendship hospital, 80 cases of liver cancer were randomly divided into experimental group in the control group, control group 40 cases were taken with conventional solution treatment, treatment group 40 cases with gemcitabine perfusion chemotherapy combined with conventional heat treatment, compared two groups of patients after treatment the curative effect and tumor cell factor level. Results The treatment group effective rate higher than the control group, the difference was statistically significant (P <0.05);Experimental group VEGF, sIL-2R, HIF-2 alpha were superior to control group, the difference was statistically significant (P <0.05). Conclusion The use of gemcitabine in patients with liver cancer hot perfusion combined with conventional chemotherapy can significantly improve the level of liver cancer patients with efficient and reduce tumor factors, is worth popularizing in clinical.