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血小板聚集抑制剂配合急诊PCI术在急性ST段抬高型心肌梗死围手术期内的临床疗效和安全性 被引量:2

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摘要 目的分析血小板聚集抑制剂配合急诊PCI术在急性ST段抬高型心肌梗死(STEMI)围手术期内的临床疗效和安全性.方法选择2017年4月~2019年3月本院收治83例行急诊PCI术的STEMI患者,按随机数字表法分为两组,对照组41例使用阿司匹林和氯吡格雷治疗,研究组42例使用阿司匹林和替格瑞洛治疗,对比两组临床疗效和安全性.结果研究组MAR(44.30±4.5)%、hs-CRP(2.07±0.37)mg/L指标低于对照组(P<0.05);研究组不良事件发生率为2.38%,比对照组低(P<0.05);且研究组社会功能(90.40±1.33)分、精神健康(92.75±1.11)分、躯体疼痛(91.76±1.13)分和一般健康(93.30±1.95)分,均比对照组高(P<0.05).结论对急诊PCI术STEMI患者使用氯吡格雷治疗,临床效果佳,但与替格瑞洛比,替格瑞洛能显著改善患者MAR、hs-CRP指标,减少不良事件,有效提高患者生活质量.
出处 《中国处方药》 2019年第8期76-77,共2页 Journal of China Prescription Drug
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  • 1葛均波,徐永健.内科学[M].第8版.北京:人民卫生出版社,2014:385-390.
  • 2Husted S,van Giezen JJ.Ticagrelor:the first reversibly binding oral P2Y12 receptor antagonist[J].Cardiovasc Ther,2009,27(4):259-274.DOI:10.1111/j.1755-5922.2009.00096.x.
  • 3Menees DS,Peterson ED,Wang Y,et al.Door-to-balloon time and mortality among patients undergoing primary PCI[J].N Engl J Med,2013,369(10):901-909.DOI:10.1056/NEJMoa1208200.
  • 4Yao J,Zhao L,Zhao Q,et al.NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis[J].Cell Death Dis,2014,5:e1283.DOI:10.1038/cddis.2014.221.
  • 5Gurbel PA,Bliden KP,Butler K,et al.Randomized doubleblind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease:the ONSET/OFFSET study[J].Circulation,2009,120(25):2577-2585.DOI:10.1161/CIRCULATIONAHA.109.912550.
  • 6Nylander S,Femia EA,Scavone M,et al.Ticagrelor inhibits human platelet aggregation via adenosine in addition to P2Y12antagonism[J].J Thromb Haemost,2013,11(10):1867-1876.DOI:10.1111/jth.12360.
  • 7Armstrong D,Summers C,Ewart L,et al.Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1[J].J Cardiovasc Pharmacol Ther,2014,19(2):209-219.DOI:10.1177/1074248413511693.
  • 8Wang K,Zhou X,Huang Y,et al.Adjunctive treatment with ticagrelor,but not clopidogrel,added to t PA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model[J].Thromb Haemost,2010,104(3):609-617.DOI:10.1160/TH09-12-0823.
  • 9van Giezen JJ,Sidaway J,Glaves P,et al.Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model[J].J Cardiovasc Pharmacol Ther,2012,17(2):164-172.DOI:10.1177/1074248411410883.
  • 10Wittfeldt A,Emanuelsson H,Brandrup-Wognsen G,et al.Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans[J].J Am Coll Cardiol,2013,61(7):723-727.DOI:10.1016/j.jacc.2012.11.032.

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