维族与汉族多囊卵巢综合征抗苗勒氏管激素水平对比及与年龄的相关性分析

Comparison of anti-mullerian hormone levels in polycystic ovary syndrome between uygur and han nationality and analysis of its relationship with age

目的对比维族与汉族多囊卵巢综合征(PCOS)抗苗勒氏管激素(AMH)水平并分析其与年龄相关性.方法将2017年5月~2019年4月某院妇科门诊收治的维族与汉族PCOS患者各40例分别设为A组、B组;另选取同期该院妇科门诊收治的维族、汉族卵巢早衰(POF)患者各40例为C组、D组.再选取同期在该院接受体检的汉族健康者40例为对照组.分别在自然或黄体酮消退后月经周期次日清晨,采集所有人员的空腹肘静脉血2 ml,通过酶联免疫吸附试验进行血清AMH水平的检测.分别比较A组、B组、对照组的血清AMH水平,C组、D组、对照组的血清AMH水平,分析不同疾病患者的血清AMH水平与年龄的关系,并作相关性分析.结果 A组、B组的血清AMH水平均分别高于对照组(P<0.05);C组、D组的血清AMH水平均分别低于对照组(P<0.05).在PCOS与POF中,31~35岁、36~40岁、≥41岁组患者的血清AMH水平均呈逐渐下降趋势,且经单因素方差分析发现:各组间对比差异有统计学意义(P<0.05).经Pearson相关性分析,PCOS、POF患者的年龄与血清AMH水平均呈负相关(P<0.05).结论维族PCOS以及POF患者的血清AMH水平高于对照组,且随着年龄的不断增加,血清AMH水平逐渐降低.

Objective To study and compare the levels of AMH in polycystic ovary syndrome( PCOS) between uygur and han nationality and analyze its correlation with age. Methods From May 2017 to April 2019, 40 uygur and han PCOS patients admitted to the department of gynaecology of our hospital were respectively recorded as group A and group B. Forty patients with premature ovarian failure( POF) of Uygur and Han nationalities admitted to gynecological clinic of our hospital during the same period were selected as group C and group D. Another 40 Han nationalities who underwent physical examination in our hospital during the same period were selected as the control group. In the morning of the next day of the menstrual cycle after natural or progesterone withdrawal, 2ml of venous blood of the fasting elbow was collected from all the subjects, and serum AMH level was detected by enzyme-linked immunosorbent assay. Serum AMH levels in group A, group B, and control group were compared, and serum AMH levels in group C, group D, and control group were compared, respectively. The relationship between serum AMH levels in patients with different diseases and age was analyzed, and the correlation was analyzed. Results Serum AMH levels in group A and group B were rise than the control group(P < 0.05). The serum AMH levels in group C and group D were lower than the control group(P < 0.05). In the PCOS and POF, the serum AMH levels of patients aged 31 ~ 35, 36 ~ 40 and 41 years showed a gradually decreasing trend, and one-way anova showed that the differences between the groups were statistically significant( all P < 0.05). Pearson correlation analysis showed that the age of PCOS and POF patients was negatively correlated with serum AMH level( all P < 0.05). Conclusion Serum AMH level of uygur patients with PCOS and POF was slightly higher than the control group, and gradually decreased with the increase of age.