Hs-CRP、PCT在小儿支气管肺炎患者中的表达及临床治疗指导价值研究

Expression of Hs-CRP and PCT in Children with Bronchial Pneumonia and Its Clinical Therapeutic Value

目的讨论采用hs-CRP、PCT检测办法,对小儿支气管肺炎患者的病情严重度评估及临床治疗有指导价值。方法方便选取2016年7月—2017年7月期间102例到该院诊治的小儿支气管肺炎患儿归入该文研究对象,通过血CRP及PCR检查、细菌培养、血清病毒学检查为患儿进行分组,分两组为细菌组与非细菌组,非细菌组感染源主要为支原体、病毒等,细菌组有患儿52例,非细菌组有患儿50例,同时选取51名健康体检患儿作为比较,命名为健康组。对3组患儿进行hs-CRP、PCT检测及联合检测,对比各组hs-CRP、PCT水平检验结果;就细菌组、非细菌组hs-CRP、PCT、联合检测的阳性率做比较。结果细菌组hs-CRP、PCT水平远比非细菌组更高,组间差异有统计学意义(P<0.05)。非细菌组hs-CRP、PCT水平较健康组而言,略增高,组间差异有统计学意义(P<0.05)。细菌组与健康组对比,患儿体内hs-CRP、PCT水平显著增高,组间差异有统计学意义(P<0.05)。对两组检测阳性率进行比较,结果发现,细菌组hs-CRP检测结果显著高于非细菌组71.15%vs34.00%(χ^2=14.12,P<0.05),PCT阳性更明显88.46%vs32.00%(χ^2=34.09,P<0.05),联合检测结果对比,细菌组阳性率更高96.15%vs56.00%(χ^2=22.84,P<0.05),组间差异有统计学意义。结论hs-CRP、PCT对细菌感染的小儿支气管肺炎具有较好检出效果,联合检测阳性率显著,能够为临床制定治疗方案提供有价值的依据。

Objective To investigate the use of hs-CRP and PCT detection methods to guide the severity and clinical treatment of bronchopneumonia in children. Methods Convenient select from July 2016 to July 2017, 102 children with bronchopneumonia who were admitted to our hospital were included in the study. The children were divided into groups by blood CRP and PCR, bacterial culture and serum virology. The two groups were bacterial group and non-bacterial group. The non-bacterial group was mainly caused by mycoplasma and virus. There were 52 cases in the bacterial group and 50 cases in the non-bacterial group. 51 healthy children were selected as the physical examination for comparison named as healthy group. The hs-CRP, PCT and combined detection were performed in three groups of children. The results of hs-CRP and PCT levels were compared. The positive rates of hs-CRP, PCT and combined detection in the bacterial and non-bacterial groups were compared. Results The levels of hs-CRP and PCT in the bacterial group were much higher than those in the non-bacterial group. The difference between the groups was statistically significant(P<0.05). The hs-CRP and PCT levels in the non-bacterial group were slightly higher than those in the healthy group, and the differences between the groups were statistically significant(P<0.05). Compared with the healthy group, the levels of hs-CRP and PCT in the bacterial group were significantly increased, and the differences between the groups were statistically significant(P<0.05). Comparing the positive rates of the two groups, the results showed that the hs-CRP test results in the bacterial group were significantly higher than those in the non-bacterial group 71.15% vs 34.00%(χ^2=14.12, P<0.05), and the PCT positive was more obvious 88.46% vs 32.00%(χ^2=34.09, P<0.05). The positive rate of the bacterial group was higher 96.15% vs 56.00%(χ^2=22.84, P<0.05). The difference between the groups was statistically significant. Conclusion hs-CRP and PCT have good detection effect on bacterial infection of children with bronchopneumonia. The positive rate of combined detection is significant, which can provide valuable evidence for clinical treatment.