超声应变力成像对诊断甲状腺良性结节纤维化的应用价值

Application value of ultrasound strain elastography in the diagnosis of benign thyroid nodule fibrosis

目的探讨超声应变力成像对诊断甲状腺良性结节纤维化的应用价值。方法选取本中心经病理证实为良性的甲状腺结节155个,术前均行超声弹性成像检查,依据病理结果将其分为伴纤维化组(n=125)、无纤维化组(n=30),并对2组间应变率比值进行对比分析。以病理结果为金标准,计算应变率比值在诊断甲状腺良性结节是否伴有纤维化的敏感度和特异度。结果伴纤维化组应变率比值[3.14(1.143,7.050)]高于良性无纤维化组[1.41(1.020,2.345)](P<0.05)。经ROC曲线分析,应变率比值>2.62,提示甲状腺良性结节可能存在纤维化,此时应变率比值的曲线下面积为0.664(0.548,0.780),敏感度为56.7%,特异度为77.6%。结论超声弹性成像应变率比值对诊断甲状腺良性结节纤维化有一定的应用价值。

Objective To investigate the application value of ultrasound strain elastography in the diagnosis of benign thyroid nodules with fibrosis. Methods A total of 155 benign thyroid nodules confirmed by pathology were selected. Ultrasound strain elastography was performed before operation. According to the pathological results,they were divided into fibrosis group (n=125) and non-fibrosis group (n=30). The ratio of strain was compared between the two groups. The sensitivity and specificity of the strain ratio in the diagnosis of benign thyroid nodules with fibrosis were calculated by using pathological results as the gold standard. Results The strain ratio was significantly higher in the fibrosis group [3.14 (1.14,7.05)] than that in the non-fibrosis group [1.41 (1.02,2.35),P<0.05]. The ROC curve showed that the stain ratio>2.62 may indicate the presence of fibrosis in the benign thyroid nodule. The area under the curve of the strain ratio was 0.664 (0.548,0.780),the sensitivity was 56.7%,and the specificity was 77.6%. Conclusion The strain ratio of ultrasound elastography has a certain value in the diagnosis of benign thyroid nodules with fibrosis.