通心络胶囊联合阿司匹林治疗2型糖尿病阿司匹林抵抗的疗效

Effect of Tongxinluo Capsules Combined with Aspirin on Aspirin Resistance in Type 2 Diabetes

目的探讨通心络胶囊联合阿司匹林治疗2型糖尿病阿司匹林抵抗(AR)的临床疗效。方法 将30例2型糖尿病AR患者按随机数字表法分为对照组和观察组,每组15例。对照组采用糖尿病的常规基础治疗,同时采用拜阿司匹林肠溶片治疗。观察组在对照组治疗的基础上加用通心络胶囊治疗。观察2组治疗1、2、3个月后血小板聚集率及临床疗效。结果 观察组总有效率为86.7%,高于对照组的66.7%( P <0.05)。治疗1、2、3个月后血小板聚集率:观察组分别为(54.56±13.34)%、(49.35±11.87)%、(47.63±12.35)%,对照组分别为(64.59± 14.87 )%、(59.56±12.75)%、(58.70±12.67)%。2组治疗2、3个月后血小板聚集率均低于治疗1个月后(均 P < 0.05 ),观察组治疗1、2、3个月后血小板聚集率均低于对照组(均 P <0.05)。结论 通心络胶囊联合阿司匹林治疗2型糖尿病AR具有较好的效果。

Objective To explore the clinical effect of Tongxinluo capsules combined with aspirin on aspirin resistance(AR) in patients with type 2 diabetes.Methods Thirty type 2 diabetes patients with AR were randomly treated with enteric-coated aspirin tablets alone(control group,n=15) or in combination with Tongxinluo capsules(observation group,n=15) based on conventional treatment.Platelet aggregation rate and clinical efficacy were observed after 1,2 and 3 months of treatment.Results The total effective rate in observation group(86.7%) was higher than that in control group(66.7%)(P<0.05).After 1,2 and 3 months of treatment,the platelet aggregation rates were respectively(54.56±13.34)%,(49.35±11.87)% and(47.63±12.35)% in observation group,and(64.59±14.87)%,(59.56±12.75)% and(58.70±12.67)% in control group.The platelet aggregation rates after 2 and 3 months of treatment were lower than those after 1 month of treatment in both groups(P<0.05),and those in observation group were lower than those in control group after 1,2 and 3 months of treatment(P<0.05).Conclusion Tongxinluo capsules combined with aspirin is effective for AR in the treatment of type 2 diabetes.