蛋白琥珀酸铁和硫酸亚铁治疗小儿缺铁性贫血的效果比较

Comparison of Iron Protein Succinate and Ferrous Sulfate for Iron Deficiency Anemia in Children

目的比较蛋白琥珀酸铁和硫酸亚铁治疗小儿缺铁性贫血的临床效果。方法 将50例缺铁性贫血患儿按随机数字表法分为试验组与对照组,每组25例。对照组予以硫酸亚铁治疗;试验组予以蛋白琥珀酸铁治疗。比较2组的临床疗效及治疗前后血红蛋白(Hb)、血清铁蛋白(SF)、血清铁水平变化情况,观察2组治疗期间不良反应发生情况。结果 2组治疗后Hb、SF及血清铁水平均较治疗前显著升高( P <0.05),且试验组较对照组升高更为显著( P <0.05);试验组治疗后临床总有效率显著高于对照组(92.00%比60.00%, P <0.05),治疗期间不良反应发生率显著低于对照组(8.00%比40.00%, P <0.05)。结论 蛋白琥珀酸铁对小儿缺铁性贫血的治疗效果显著,临床应用价值较硫酸亚铁高,不良反应少。

Objective To compare the effect of iron protein succinate and ferrous sulfate on iron deficiency anemia in children. Methods Fifty children with iron deficiency anemia were randomly assigned to receive either ferrous sulfate(control group, n =25) or iron protein succinate(experimental group, n =25).The levels of hemoglobin(Hb),serum ferritin(SF) and serum iron were measured before and after treatment.In addition,the clinical efficacy and adverse reactions were compared between the two groups. Results After treatment,the levels of Hb,SF and iron increased in both groups,and the increase in experimental group was more obvious than that in control group( P <0.05).Compared with control group,iron protein succinate treatment increased the total effective rate(92.00% vs 60.00%, P <0.05),and decreased the incidence of adverse reactions(8.00% vs 40.00%, P <0.05). Conclusion Iron protein succinate is effective for treating iron deficiency anemia in children.Furthermore,iron protein succinate has a higher clinical value and results in a lower incidence of adverse reactions than ferrous sulfate.