硫酸吲哚酚对心血管毒性作用的研究进展

Research progress in the toxic effect of indoxyl sulfate on cardiovascular system

慢性肾脏病(chronic kidney disease,CKD)患者心血管疾病(cardiovascular disease,CVD)的发生率高且预后极差,了解CKD患者中CVD发生发展的病理生理变化有助于制定相关治疗策略以降低其发病率和死亡率。一般人群的传统心血管危险因素,如糖尿病、高血压和血脂异常等,在CKD患者中更为常见,但这仍然不足以完全解释其心血管事件高风险的特点。随着肾功能下降,积聚在体内的尿毒症毒素被认为在CKD患者CVD的发生与发展过程中起关键的促进作用,而硫酸吲哚酚(indoxyl sulfate,IS)是当前研究最多的肠源性尿毒素之一。该文就IS对心血管毒性作用的相关研究进展作一综述。

The incidence of cardiovascular diseases(CVD) is increased in patients with chronic kidney disease(CKD) and the prognosis is extremely poor. Understanding the pathophysiological changes in the development of CVD in patients with CKD helps to develop relevant treatment strategies to reduce the high morbidity and mortality. Traditional cardiovascular risk factors of CVD such as diabetes, hypertension and dyslipidemia in the general population are more common than those in CKD patients, but these factors are still not sufficient to fully explain their increased cardiovascular risks. As renal function declines, uremic toxins accumulating in the body are thought to play a key role in the development and progression of CVD in patients with CKD, and indoxyl sulfate(IS) is one of the most studied enterogenous urinary toxins. In this paper, we review the research progress in the toxic effect of IS on the cardiovascular system.