ATP敏感性钾通道在降钙素基因相关肽心肌保护中作用的研究进展

Advances in research on the role of ATP-sensitive potassium channel in cardioprotection of calcitonin generelated peptide

降钙素基因相关肽(calcitonin gene-relatedpe ptide,CGRP)是一种可强烈舒张血管的感觉神经肽,具有减轻心肌缺血/再灌注损伤(myocardial ischemia/reperfusion injury,MI/RI)的作用,但其具体机制仍不清楚。心肌三磷酸腺苷(ATP)敏感性钾通道(KATP)具有联系细胞新陈代谢与细胞膜的兴奋性的作用,涉及对心率失常及心衰的保护。而KATP可能是CGRP减轻MI/RI作用通路中的关键节点。该文就KATP在CGRP心肌保护中的作用作一综述,阐述CGRP减轻MI/RI的作用机制。

Calcitonin gene-related peptide(CGRP) is a kind of sensory neuropeptide that can strongly vasodilate blood vessels and has the effects of reducing myocardial ischemia/reperfusion injury(MI / RI), but the exact mechanism is still unknown. Myocardial ATP-sensitive potassium channels(K ATP ) have the effect of associating cell metabolism with the excitability of the cell membrane and involve the protection of arrhythmias and heart failure. Moreover, K ATP channel may be a key node in the pathway of CGRP to reduce MI/RI. This paper aims at stating the role of K ATP in myocardial protection of CGRP, and the mechanism of CGRP in reducing MI/RI is further described.