肺结节病发病机制研究进展

Advances in research on pathogenesis of pulmonary sarcoidosis

结节病是一种原因不明的多系统累及的肉芽肿性疾病,主要侵犯肺和淋巴系统,其次是眼部和皮肤.肉芽肿是最复杂的免疫反应之一,涉及多种细胞,且细胞分子间的相互作用随时间而动态变化.近年对结节病发病机制的新见解不断涌现,包括结节病的先天免疫、Th17细胞、Treg细胞、血清淀粉样蛋白A(serum amyloid A protein,SAA)和其他因素的作用.

Sarcoidosis is an unexplained granulomatous disease involving multi-system. Sarcoidosis primarily affects lung and lymphatic system, followed by eyes and skin. Granuloma is one of the most complex immune responses involving multiple cells, dynamic intercellular molecular interactions, and changes over time. In recent years, new insights into the pathogenesis of sarcoidosis have emerged. This article will review recent advances in the pathogenesis of pulmonary sarcoidosis, including innate immunity of sarcoidosis, Th17 cells, Treg cells, serum amyloid A, and other factors.