Omentin-1及内脏脂肪厚度与妊娠期糖尿病相关性研究进展

Progress in the correlation between omentin-1 and visceral fat thickness and gestational diabetes mellitus

妊娠期糖尿病(gestational diabetes mellitus,GDM)定义为妊娠期首次发生或发现的糖尿病.近年来在中国,随着人们生活水平及孕妇产检率的提高,GDM的检出率也有明显增加的趋势,严重威胁到母儿健康,因此对GDM的研究显得愈发重要.有研究表明妊娠早期内脏脂肪组织厚度的测量可以预测妊娠24~28周时葡萄糖稳态受损,选择性表达于内脏脂肪中的脂肪因子网膜素-1(omentin-1)可以促进人体皮下及网膜脂肪细胞对胰岛素介导的葡萄糖摄取及信号转导途径磷酸化作用,有效改善胰岛素的敏感性,鉴于胰岛素抵抗是GDM的重要发病机制,内脏脂肪厚度、血清omentin-1与GDM之间可能存在相关性.

Gestational diabetes mellitus (GDM) is defined as diabetes that occurs or is first detected during pregnancy. In recent years, with the improvement of people's living standards and maternal check-up rate in China, the detection rate of GDM has also increased significantly, which seriously threatens the health of mother and child. Therefore, research on GDM is becoming more and more important. Studies have shown that the measurement of visceral adipose tissue thickness in early pregnancy can predict glucose homeostasis at 24–28 weeks of gestation, and omentin-1, which is selectively expressed in visceral fat, can promote subcutaneous and subcutaneous omental fat cells have insulin-mediated glucose uptake and phosphorylation of signaling pathways, which effectively improve insulin sensitivity. Insulin resistance is an important pathogenesis of GDM. We speculate that visceral fat thickness, serum omentin-1 and GDM There is a correlation between them. This article reviews the progress of visceral fat thickness and serum omentin-1 levels and GDM in pregnant women.