慢性心力衰竭与淋巴细胞和细胞因子相关性的研究进展

Research progress on the relationship between chronic heart failure and lymphocytes and cytokines

慢性心力衰竭(CHF)是一种复杂的临床症状群,其作为大部分心血管疾病的最终归宿,是心脏病最主要的死因之一。CHF的发病机制复杂,近年来,随着研究的深入,发现免疫因素在其疾病过程中发挥了重要作用。B淋巴细胞和T淋巴细胞通过不同的作用方式对心肌产生损害,诱发及加重病理性心室重构,最终加快CHF的发生发展。以肿瘤坏死因子-α和白细胞介素-6为代表的具有促炎作用的细胞因子,能加快CHF病程的发展。而IL-33等细胞因子则具有保护心脏的作用,可以延缓CHF的病程进展。本文综述了近年来与CHF的发生、发展过程中相关淋巴细胞和细胞因子的研究进展,以期为未来其临床治疗提供新思路。

Chronic heart failure (CHF) is a complex clinical symptom group.As the ultimate outcome of most cardiovascular diseases,it is one of the main causes of death of heart disease.The pathogenesis of CHF is complex.In recent years,with the deepening of research,it has been found that immune factors play an important role in the disease process.B lymphocyte and T lymphocyte damage myocardium through different ways of action,induce and aggravate pathological ventricular remodeling,and ultimately accelerate the occurrence and development of CHF.Tumor necrosis factor-α and interleukin-6,as the representatives of proinflammatory cytokines,can accelerate the development of CHF.Cytokines such as IL-33 can protect the heart and delay the progression of CHF.This article reviews the recent research progress of lymphocytes and cytokines related to the occurrence and development of CHF in order to provide new ideas for its clinical treatment in the future.