口腔鳞状细胞癌肿瘤微环境细胞间相互作用的研究进展

Advances in research on cell-cell interactions in oral squamous cell carci-noma tumor microenvironment

口腔鳞状细胞癌(OSCC)肿瘤微环境(TME)中包括肿瘤细胞、肿瘤相关巨噬细胞(TAMs)、肿瘤相关成纤维细胞(CAFs)、内皮细胞等。在OSCC的发生、发展过程中,肿瘤细胞产生某些物质影响TAMs和CAFs的募集、分化、活化等行为,TAMs和CAFs分泌细胞因子促进肿瘤细胞增殖、侵袭、转移等活动,它们之间的交互作用形成了有利的TME,在肿瘤发生发展的各个阶段起重要作用。本文就肿瘤细胞分别与TAMs和CAFs的交互作用以及CAFs对TAMs的作用的最新进展作一综述。

Oral squamous cell carcinoma (OSCC) tumor microenvironment (TME) includes tumor cells,tumor-associated macrophages (TAMs),tumor-associated fibroblasts (CAFs),and endothelial cells.During the occurrence and development of OSCC,tumor cells produce certain substances that affect the recruitment,differentiation and activation of TAMs and CAFs.TAMs and CAFs secrete cytokines to promote tumor cell proliferation,invasion,metastasis and other activities.The interaction between them forms a favorable TME,which plays an important role in the various stages of tumorigenesis and development.This article reviews the recent advances in the interaction of tumor cells with TAMs and CAFs and the role of CAFs in TAMs.