糖尿病患者眼表指标BUT、FL、SRI、SIt变化分析

Analysis of changes of ocular surface index BUT, FL, SRI and SIt in diabetic patients

目的分析糖尿病患者眼表指标BUT、FL、SRI、SIt变化。方法选择2018年1~6月本院收治的糖尿病患者50例为糖尿病组,另选择同期健康体检者50例为对照组。比较两组眼表疾病指数(OSDI)、泪河高度、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分、睑板腺缺失评分、角膜表面规则指数(SRI)、泪液分泌试验(SIt)。结果糖尿病组OSDI评分为(15.1±2.1)分,对照组为(8.0±1.3)分,两组比较差异有统计学意义(P<0.05)。对照组泪河高度(0.22±0.03)mm,糖尿病组泪河高度(0.17±0.02)mm,两组比较差异有统计学意义(P<0.05)。对照组FL评分(0.51±0.11)分,糖尿病组(1.80±0.19)分,两组比较差异有统计学意义(P<0.05)。对照组SIt(10.0±2.5)mm,糖尿病组(7.1±1.3)mm,两组比较差异有统计学意义(P<0.05)。自然状态以及持续睁眼10 s后,对照组SRI均显著低于糖尿病组,差异有统计学意义(P<0.05)。结论糖尿病患者容易发生眼表损害,存在泪膜功能下降、泪液分泌量减少、角膜上皮不规则等情况,临床工作中应注意预防,早期发现,及时治疗。

Objective To analyze ocular surface index BUT, FL, SRI and SIt in diabetic patients. Methods From January to June 2018, 50 patients with diabetes mellitus were selected from our hospital as the diabetes mellitus group,and 50 cases for healthy physical examination were selected as the control group. The ocular surface disease index(OSDI), lacrimal river height, tear film rupture time(BUT), corneal fluorescein staining(FL) score, tarsal gland loss score,corneal surface regularity index(SRI), and tear secretion test(SIt) were compared between the two groups. Results OSDI score of diabetes mellitus group was(15.1±2.1)points, and that of control group was(8.0±1.3)points. There was significant difference between the two groups(P<0.05). The height of lacrimal river in the control group was(0.22±0.03) mm,and that in the diabetic group was(0.17±0.02) mm, the difference between the two groups was statistically significant(P<0.05). The FL score of the control group was(0.51±0.11), and that of the diabetes group was(1.80±0.19), the difference was statistically significant between the two groups(P<0.05). SIt in the control group was(10.0±2.5) mm, and(7.1±1.3) mm in the diabetic group, and the difference was statistically significant between the two groups(P<0.05).The SRI of the control group was significantly lower than that of the diabetic group at natural state and after 10 seconds of continuous eye opening, the difference was statistically significant(P<0.05). Conclusion Diabetes mellitus patients are prone to ocular surface damage, tear film function decline, tear secretion reduction, corneal epithelial irregularity and other conditions, clinical work should pay attention to prevention, early detection, timely treatment.