多药联合治疗妊娠期肝内胆汁瘀积症的观察

Observation on the Treatment of Intrahepatic Cholestasis of Pregnancy With Multidrug Combination Therapy

目的分析多药联合治疗妊娠期肝内胆汁瘀积症的治疗效果。方法选取我院2017年9月—2018年9月收治的妊娠期肝内胆汁瘀积症患者40例作为研究对象。以抛硬币的方式,将其分为观察组与对照组,每组各20例。两组患者分别采用不同的药物治疗方式,观察组采用多药联合治疗方式,对照组则采用熊去氧胆酸治疗。治疗15日后,比较与观察两组患者治疗前后生化指标的变化以及临床疗效。结果观察组患者治疗后的TBA、ALT、AST指标分别为(10.61±2.13)μmol/L、(58.77±29.01)U/L、(50.02±20.83)U/L,均优于对照组结果,差异具有统计学意义(P<0.05)。观察组患者治疗总有效率为95.00%,高于对照组,差异具有统计学意义(P<0.05)。结论将多药联合治疗方式应用于妊娠期肝内胆汁瘀积症治疗中可以明显改善患者的各项指标,治疗效果较为明显。

Objective To analyze the therapeutic effect of multi-drug combination therapy for intrahepatic cholestasis of pregnancy. Methods 40 patients with intrahepatic cholestasis of pregnancy admitted to our hospital from September 2017 to September 2018 were selected as the study subjects. In the way of coin tossing, they were divided into observation group and control group, 20 cases in each group. Two groups of patients were treated with different drugs. The observation group was treated with multi-drug combination therapy. The control group was treated with ursodeoxycholic acid. After 15 days of treatment, the changes of biochemical indexes and clinical efficacy of the two groups before and after treatment were compared and observed. Results The TBA, ALT and AST indexes of the observation group were (10.61±2.13)μmol/L,(58.77±29.01)U/L,(50.02±20.83) U/L, which were better than the control group, the difference was statistically significant (P<0.05). The total effective rate of the observation group was 95.00%, which was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion The application of multi-drug combination therapy in the treatment of intrahepatic cholestasis of pregnancy can significantly improve the various indicators of patients, and the therapeutic effect is more obvious.