腹腔镜结直肠癌根治术治疗结直肠癌临床疗效及对患者胃肠功能的影响

Clinical study of laparoscopic radical resection in the treatment of colorectal cancer in and its influence on gastrointestinal function

目的:探讨腹腔镜结直肠癌根治术治疗结直肠癌患者的临床疗效及对胃肠功能的影响。方法:127例结直肠癌患者随机分为观察组(n=46)和对照组(n=63)。对照组给予传统开腹结直肠癌根治术,观察组给予腹腔镜下结直肠癌根治术治疗。观察两组术中出血量、手术时间、住院时间,淋巴结清扫数量,术后并发症发生情况,肠鸣音恢复时间、术后排气时间、进食时间等胃肠功能及SF-36评分。结果:观察组术中出血量及住院时间均低于对照组(t=-13.527,P=0.000;t=-10.931,P=0.000),而手术时间高于对照组(t=4.624,P=0.000)。观察组淋巴结清扫数量与对照组比较差异无统计学意义(t=1.948,P=0.000)。观察组肠鸣音恢复时间、术后排气时间、进食时间均低于对照组(t=-13.583,P=0.000;t=-7.884,P=0.000;t=-14.325,P=0.000)。术后,两组SF-36评分与治疗前比较均显著升高(t=8.111,P=0.000;t=6.804,P=0.001);观察组SF-36评分(81.32±21.47)显著高于对照组(74.21±17.89)(t=2.029,P=0.045)。观察组术后并发症发生率4.69%显著低于对照组15.87%(χ~2=4.323,P=0.038)。结论:腹腔镜结直肠癌根治术治疗结直肠癌临床疗效显著,可有效减少术中出血量、缩短住院时间、促进胃肠功能恢复、改善患者预后、提高患者生活质量、安全性高。

Objective: This study aims to investigate the clinical efficacy of laparoscopic radical resection of colorectal cancer and its effect on gastrointestinal function. Methods: 127 patients admitted were randomly divided into observation group(n=46) and control group(n=63). The control group was treated by traditional open radical resection of colorectal cancer, while the observation group was treated by laparoscopic radical resection of colorectal cancer. It observed and compared the volume of intraoperative bleeding, operation time, hospitalization time, the number of lymph node dissection, postoperative complication, recovery time of bowel sounds, postoperative exhaust time, eating time, gastrointestinal function and SF-36 score between the two groups.Results:The volume of intraoperative bleeding and hospitalization time in the observation group were lower than those in the control group(t=-13.527,P=0.000;t=-10.931, P=0.000). While, the operation time in the observation group was higher than that in the control group(t=4.624, P=0.000). There was no significant difference in the number of lymph node dissection between the observation group and the control group(t=1.948,P=0.000). The recovery time of bowel sounds, exhaust time and eating time in the observation group were lower than those in the control group(t=-13.583,P=0.000;t=-7.884, P=0.000;t=-14.325,P=0.000). After operation, the SF-36 score of the two groups were significantly higher than those before treatment(t=8.111,P=0.000;t=6.804,P=0.001). In addition, the SF-36 scores of(81.32±21.47)in the observation group was significantly higher than that of(74.21±17.89)in the control group(t=2.029, P=0.045). The incidence of postoperative complication of 4.69% in the observation group was significantly lower than that of 15.87% in the control group(χ~2=4.323, P=0.038). Conclusion:Laparoscopic radical resection of colorectal cancer has a significant clinical effect. It can effectively reduce intraoperative bleeding, shorten hospitalization time, promote the recovery of gastrointestinal function, improve the prognosis of patients, improve the quality of life of patients. It is worthy of promotion and application.