妊娠期抗抑郁药物的合理应用

Rational Application of Antidepressants in Pregnancy

妊娠期用药的研究受医学伦理学等因素的影响,迄今为止仍是临床药理学和药物研究发展最缓慢和最受忽视的领域之一。由于妊娠期独特的母体生理学变化和胎儿发育的易损性,使得妊娠期妇女的合理用药问题被广泛关注。抑郁症是一种慢性精神疾病,具有患病率高、致残率高、复发率高和自杀率高等特点,因此抑郁症妇女妊娠期抗抑郁药物应用的安全性及必要性,成为临床治疗面临的一大难题。本文主要就妊娠期抗抑郁药物的合理应用进行详述。

The study of drug use during gestation is influenced by many factors other than medical ethics.It is still one of the most easily neglected fields with the slowest development in clinical pharmacology and pharmaceutical research.Due to unique changes in maternal physiology and the vulnerability of fetal development during pregnancy,rational use of drugs in pregnancy has been widely concerned.Depression is a kind of chronic mental disease characterized by high prevalence rate, high disability rate,high recurrence rate,and high suicide rate.Therefore,the safety and necessity of antidepressant use during pregnancy in depressed women has become a major problem in clinical treatment.This paper detailedly discusses the rational application of antidepressants in pregnancy.