血清PCT,SOD水平检测在腹膜透析相关性腹膜炎中的临床价值

Clinical Value of Serum PCT and SOD in Detection of Peritoneal Dialysis

目的探讨血清降钙素原(PCT)和超氧化物歧化酶(SOD)水平与腹膜透析相关性腹膜炎(peritoneal dialysis,PD)的相关性及其检测的临床价值。方法①选取铜川市人民医院2016年1月~2018年12月收治的123例腹膜透析患者作为研究对象,其中发生PD 48例(腹膜炎组),未发生PD 75例(无腹膜炎组),选取同期53例非透析患者人群作为对照组,观察PCT和SOD水平;②将研究对象按PCT和SOD水平分层,观察PCT和SOD水平与PD的相关性。结果腹膜炎组、无腹膜炎组和对照组的PCT水平分别为2.249±0.671,0.833±0.443和0.038±0.004 ng/ml,各组之间差异均有统计学意义(F=475.721,P=0.000);腹膜炎组、无腹膜炎组和对照组的SOD水平分别为74.6±15.5,95.2±20.0和136.1±21.8 U/ml,各组之间差异均有统计学意义(F=52.276,P=0.000);腹膜炎发生与PCT水平呈正相关(r^2=0.9721,P=0.021),与SOD水平呈负相关(r^2=-0.875 6,P=0.037)。结论 PCT水平越高,SOD水平越低,则腹膜炎的发生风险越大。PCT和SOD水平能够反映PD的生理病理过程,对PD的诊断和评估具有一定的临床价值。

Objective To investigate the correlation of serum procalcitonin(PCT) and superoxide dismutase(SOD) levels with peritoneal dialysis(PD) and its clinical value.Methods ①123 cases of peritoneal dialysis patients were selected as the research object,the PD 48 patients with peritonitis(peritonitis group),75 cases without PD is no peritonitis(no peritonitis group),the selection of the 53 patients with non dialysis population for the same period as the blank control group,all patients PCT and SOD testing,observation SOD levels of PCT and its relationship with PD.②Dialysis patients were stratified according to PCT and SOD levels to observe the correlation between PCT and SOD levels and PD.Results The PCT level of the peritonitis group(2.249±0.671 ng/ml) was higher than that of the peritonitis group(0.833±0.443 ng/ml) and the control group(0.038±0.004 ng/ml),and the difference was statistically significant(F=475.721,P=0.000).The SOD level of the peritonitis group(74.6±15.5 U/ml) was lower than that of the peritonitis group(95.2±20.0 U/ml) and the control group(136.1±21.8 U/ml),and the difference was statistically significant(F=52.276,P=0.000).Peritonitis was positively correlated with PCT level(r^2=0.972 1,P=0.021) and negatively correlated with SOD level(r^2=-0.875 6,P=0.037).Conclusion With the increase of PCT level,the risk of peritonitis increased,which was negatively correlated with SOD level.PCT and SOD levels can reflect the physiological and pathological process of PD,and have certain clinical value for the diagnosis and evaluation of PD.