前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床效果评价

Clinical Evaluation of Alprostadil Combined with Benazepril in the Treatment of Diabetic Nephropathy with Proteinuria

目的:探讨前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床效果。方法:纳入笔者所在医院2017年6月13日-2018年5月17日收治的糖尿病肾病蛋白尿患者80例。随机数字表分组,单药干预组采取前列地尔治疗,联合干预组则采取前列地尔加上贝那普利治疗。比较单药干预组、联合干预组疗效,尿微量白蛋白降低50%时间、症状体征消失时间,治疗前后患者尿微量白蛋白排泄量、24 h尿蛋白水平,不良反应。结果:联合干预组疗效、尿微量白蛋白降低50%时间、症状体征消失时间、尿微量白蛋白排泄量、24 h尿蛋白水平均优于单药干预组,差异均有统计学意义(P<0.05)。联合干预组不良反应发生率和单药干预组比较差异无统计学意义(P>0.05)。结论:前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的效果理想。

Objective:To evaluate the clinical effect of Alprostadil combined with Benazepril in the treatment of diabetic nephropathy with proteinuria.Method:A total of 80 patients with diabetic nephropathy proteinuria in our hospital were enrolled in our hospital from June 13 rd,2017 to May 17 th,2018.The random number table was grouped,the monotherapy intervention group was treated with Alprostadil,and the combined intervention group was treated with Alprostadil combined with Benazepril.The efficacy,the time of urinary microalbumin was reduced by 50%,the time of disappearance of symptoms and signs,the amount of urinary albumin excretion and 24 h urine protein level before and after treatment,and adverse reactions of monotherapy intervention group and combined intervention group were compared.Result:The efficacy of the combined intervention group,the time to reduce urinary albumin by 50%,the disappearance of symptoms and signs,the amount of urinary albumin excretion,and the 24 h urine protein level were better than those in the single-agent intervention group(P<0.05).There was no significant difference of the adverse reaction group between the monotherapy intervention group and the combined intervention group(P>0.05).Conclusion:Alprostadil combined with Benazepril is effective in the treatment of diabetic nephropathy proteinuria.