炎症诱导嗅鞘胶质细胞应激功能障碍的研究进展

Advances in Research on Stress Dysfunction of Olfactory Ensheathing Glia Induced by Inflammation

神经损伤在临床上很常见,外科技术的发展已经在很大程度上提高了修复的质量,但修复的效果仍然不理想。嗅鞘胶质细胞是极少数的中枢神经系统可以再生的细胞之一,具有很强的促进神经修复再生和神经髓鞘化的能力,它的发现为神经系统再生医学领域带来了新的希望。然而,炎症应激下,嗅鞘胶质细胞的活性降低或发生死亡,明确嗅鞘胶质细胞在炎症条件下细胞死亡的具体病理分子过程非常重要。本文对近年来的最新研究进展进行综述,并且对存在的问题提出讨论和假设。

Nerve damage is very common in the clinic.The development of surgical techniques has greatly improved the quality of repair,but the effect of repair is still not ideal.Olfactory ensheath glial cells are one of the few cells that can be regenerated by the central nervous system.They have strong ability to promote nerve repair regeneration and neuro myelination.Its findings have brought new hope to the field of neurological regenerative medicine.However,under inflammatory stress,the activity of olfactory ensheathing glial cells is reduced or killed,and it is important to understand the specific pathological molecular processes of olfactory ensheathing glial cells under inflammatory conditions.This paper reviews the latest research progress in recent years and discusses and hypotheses the existing problems.