腹腔热灌注化疗治疗卵巢癌恶性腹腔积液的效果观察

Therapeutic Effect of Intraperitoneal Hyperthermic Perfusion Chemotherapy on Malignant Peritoneal Effusion of Ovarian Cancer

目的:探讨通过腹腔镜下置管,进行腹腔热灌注化疗治疗卵巢癌恶性腹腔积液的临床初步疗效及安全性,为临床治疗提供一种不同的选择。方法:选取厦门市海沧医院2015年3月-2018年6月间收治的46例晚期卵巢癌伴恶性腹腔积液患者为研究对象,根据治疗方案的不同分为治疗组(26例)和对照组(20例),治疗组患者采用紫杉醇静脉化疗联合顺铂腹腔热灌注化疗,对照组患者采用紫杉醇联合顺铂静脉化疗,评价两组患者治疗的近期有效率、生活质量及毒副反应。结果:治疗组的近期有效率及KPS评分改善率分别为84.6%、76.9%,均显著高于对照组(50.0%、45.0%),差异有统计学意义(P<0.05);在毒副反应方面,两组有所差异,试验组腹痛、腹胀发生比例较高,而对照组的骨髓抑制发生比例较高,但两组均未出现严重毒副反应,总的毒副反应发生率两组比较,差异无统计学意义(P>0.05)。结论:腹腔热灌注化疗可显著提高卵巢癌恶性腹腔积液患者的近期临床疗效及生活质量,且毒副反应轻微,值得在临床推广应用。

Objective:To investigate the preliminary clinical efficacy and safety of laparoscopic catheterization and intraperitoneal hyperthermic perfusion chemotherapy in the treatment of Malignant peritoneal effusion of ovarian cancer,and to provide a different choice for clinical treatment.Method:46 cases of advanced ovarian cancer with malignant peritoneal effusion admitted to Haicang Hospital of Xiamen City from March 2015 to June 2018 were selected as the research objects.According to the different treatment schemes,the patients in the treatment group were divided into treatment group(26 cases) and control group(20 cases).The patients in the treatment group were treated with paclitaxel intravenous chemotherapy combined with cisplatin intraperitoneal hyperthermic perfusion chemotherapy,while those in the control group were treated with paclitaxel combined with cisplatin intra,to evaluate the short-term efficacy,quality of life and toxicity of the two groups.Result:The short-term effective rate and KPS score improvement rate of the treatment group were 84.6% and 76.9% respectively,which were significantly higher than 50.0% and 45.0% of the control group with statistical significance(P<0.05).In terms of toxicity and side effects,there were differences between the two groups.The incidence of abdominal pain and abdominal distension was higher in the experimental group,while the incidence of bone marrow suppression was higher in the control group,but there were no serious toxic and side effects in both groups.There was no significant difference in the total incidence of side effects between the two groups(P>0.05).Conclusion:Intraperitoneal hyperthermic perfusion chemotherapy can significantly improve the short-term clinical efficacy and quality of life of patients with malignant peritoneal effusion of ovarian cancer,and the toxicity and side effects are mild,which is worthy of clinical application.