非小细胞肺癌患者中血清HE4、CA153水平检测及意义分析

Detection of Serum HE4 and CA153 Levels in Patients with Non-small Cell Lung Cancer and Its Significance

目的:检测非小细胞肺癌(NSCLC)患者中血清人附睾蛋白4(HE4)、糖类抗原153(CA153)水平,并分析其临床意义。方法:回顾性分析64例NSCLC患者与61例肺炎患者、同期在笔者所在医院进行体检的62例健康者的临床资料,分别设置为A组、B组、C组,比较三组血清HE4、CA153水平,A组不同病理类型、不同分期、不同预后情况血清HE4、CA153水平。结果:A组血清HE4、CA153水平均高于B组,B组均高于C组,差异均有统计学意义(P<0.05)。A组不同病理类型血清HE4、CA153水平比较差异无统计学意义(P>0.05);A组Ⅲ~Ⅳ期患者血清HE4、CA153水平高于Ⅰ~Ⅱ期患者,差异有统计学意义(P<0.05)。A组死亡患者血清HE4、CA153水平高于存活患者,差异有统计学意义(P<0.05)。结论:血清HE4、CA153可作为NSCLC诊断、分期、预后评估的有效指标。

Objective:To detect the levels of serum HE4 and CA153 in patients with NSCLC and analyze its clinical significance.Method:The clinical data of 64 patients with NSCLC and 61 patients with pneumonia and 62 healthy subjects who underwent physical examination in our hospital were retrospectively analyzed.They were divided into group A,group B and group C.The serum levels of HE4 and CA153 of three gruops,different pathological types and different stages,different prognosis of group A were compared.The value of diagnosing NSCLC when the two tested separately and combined were compared.Result:The levels of serum HE4 and CA153 of group A were higher than those of group B,of which the group B were higher than those of group C,the differences were statistically significant(P<0.05).There was no significant difference in serum HE4,CA153 levels among different pathological types in group A(P>0.05).The levels of serum HE4 and CA153 in group A patients with stage Ⅲ-Ⅳ were higher than those in stage Ⅰ-Ⅱ(P<0.05).The level of serum HE4,CA153 of dead patientsin group A was higher than that of survival patients(P<0.05).Conclusion:Serum HE4 and CA153 can be used as effective indicators for the diagnosis,staging and prognosis of NSCLC.