结直肠癌干细胞和微环境对结直肠癌转移的影响

Effects of Colorectal Cancer Stem Cells and Microenvironment on Metastasis of Colorectal Cancer

结直肠癌是最常见的癌症之一,过去虽然对早期结直肠癌的治疗已取得了长足进步,但其转移机制尚不清楚,针对结直肠癌的转移尚无有效治疗方法,而远处转移是结直肠癌引起死亡的主要原因。结直肠癌干细胞的存在促进了结直肠癌的发生发展,而基质细胞与结直肠癌细胞发生物质交换,为结直肠癌细胞提供营养物质,因此结直肠癌干细胞与癌细胞所处的微环境对结直肠癌发生远处转移起着至关重要的作用。未来,对结直肠癌干细胞和微环境的深入研究可以预防和治疗结直肠癌的转移,并为发生远处转移的结直肠癌患者的治疗提供新思路。

Colorectal cancer is one of the most common cancers.Although great progress has been made in the treatment of early colorectal cancer in the past,the mechanism of metastasis is still unclear.There is no specific effective treatment for metastasis of colorectal cancer,and distant metastasis is the main cause of death of colorectal cancer.The existence of colorectal cancer stem cells promotes the occurrence and the development of colorectal cancer.Material exchange between stromal cells and colorectal cancer cells provides nutrients for colorectal cancer cells.Therefore,the microenvironment of colorectal cancer stem cells and cancer cells plays an important role in the distant metastasis of colorectal cancer.In the future ,in-depth study of colorectal cancer stem cells and the microenvironment can provide new ideas for the prevention and treatment of colorectal cancer metastasis,and treatment of the distant metastasis.