丁苯酞序贯疗法对急性脑梗死的临床疗效及血清白细胞介素-6、金属基质蛋白酶-2、金属基质蛋白酶-9的影响

The effect of butylphthalide sequential therapy on acute cerebral infarction and its effect on serum IL-6、MMP-2 and MMP-9

目的:探讨丁苯酞序贯疗法对急性脑梗死的临床疗效及血清白细胞介素6(IL-6)、金属基质蛋白酶-2(MMP-2)、金属基质蛋白酶-9(MMP-9)的影响。方法:选取急性脑梗死患者,按随机数字表法,将80例急性脑梗死患者随机分为两组,对照组(40例)在常规治疗组,序贯组(40例)为常规治疗上加用丁苯酞注射液,治疗14 d后,使用丁苯酞软胶囊至第90天。于治疗前、治疗7 d、14 d、90 d检测两组患者血清IL-6、MMP-2、MMP-9的变化,对比两组患者运用不同干预方法的临床效果。结果:序贯组在治疗7 d、14 d、90 d时,血清IL-6、MMP-2、MMP-9水平较对照组明显降低,差异有统计学意义(P<0.05);运用不同方法干预治疗90 d后,序贯组患者的治疗有效率为97.5%,显著高于对照组(85.0%),两组数据比较,差异有统计学意义(P<0.05);序贯组患者的NIHSS、ADL评分优于对照组,两组数据比较差异有统计学意义(P<0.05)。结论:急性脑梗死患者运用丁苯酞序贯疗法干预治疗可显著降低患者IL-6、MMP-2、MMP-9的水平,提高了患者的生活能力及神经功能水平。

Objective To investigate the clinical efficacy of butylphthalide sequential therapy for acute cerebral infarction and to study the effects on serum IL-6、MMP-2 and MMP-9. Method 80 cases of acute cerebral infarction patients were admitted to our hospital, according to the method of random, the patients were divided into contral group (40 cases)with conventional therapy and se-quential therapy group (40 cases)with Conventional treatment plus Butylphthalide injection for 14 days, and then use Butylphthalide Soft Capsules to 90 days.The le-vels of serum IL-6, MMP-2 and MMP-9 in 2 groups were detected before treatment, 7 days,14 days and 90 days after treatment and the clinical effects of different interventions were compared between the two groups. Results The serum IL-6, MMP-2 and MMP-9 levels in the sequential group were significantly lower than those in the cont-rol group on the 7 day, the 14 day and the 90 day after treatment,two groups of data showed significant difference( P <0.05).Patients were treated with different methods for 90 days,the effective rate of 97.5% of sequential group was significantly higher than that of control group 85.0%, two groups of data showed significant difference ( P <0.05);The NIHSS and ADL scores in sequential group were better than those in the control group,there was a significant difference in the comparison between the two groups ( P <0.05). Conclusion The use of butylphthalide sequential therapy in patients with acutecerebral infarction can significantly reduce the level of IL-6, MMP-2 and MMP-9, and improve the patient's ability to live and the level of nerve function.