腹膜腔细胞的免疫特性及功能研究进展

Advances in research on immune characteristics and function of peritoneal cells

腹膜腔内含有大量的免疫细胞,主要是腹膜腔巨噬细胞和腹膜腔B细胞。腹膜腔巨噬细胞是一群异质性细胞,以高表达F4/80(F4/80hi)大腹膜腔巨噬细胞为主,主要作用是维持组织稳态;在炎症或病理条件下通过多种方式发挥免疫调节和组织修复作用;但也会因为抑制NK/T细胞功能而增加部分肿瘤负荷和转移概率。腹膜腔B细胞主要通过分泌IL-10发挥免疫调节作用。两种细胞可以相互协同,都在机体保护、免疫调节方面发挥重要作用。本文就腹膜腔细胞特性及功能结合国内外文献予以总结阐述。

A great number of immune cells exist in peritoneal cavity,which mainly consist of peritoneal macrophages and peritoneal B cells.Peritoneal macrophages,mainly represented by high expression of F4/80 (F4/80 hi ) large peritoneal macrophages,are heterogeneous cells with the function of maintaining tissue homeostasis.They can modulate immune system and repair tissue in many ways under inflammatory or pathology conditions,while they can also increase tumor burden or probability of metastasis through inhibiting NK/T cell function.Peritoneal B cells play an immunomodulatory role mainly by secreting IL-10.The two kinds of cells can cooperate with each other and play an important role in the protection of the body and immune regulation.This article summarizes the characteristics and functions of peritoneal cells combined with domestic and foreign literature.