甲基强的松龙与中剂量环磷酰胺联合治疗重症肌无力危象的临床疗效分析

Clinical Efficacy of Methylprednisolone Combined with Middle Dose Cyclophosphamide in the Treatment of Myasthenia Gravis Crisis

目的分析甲基强的松龙中剂量环磷酰胺联合治疗重症肌无力危象的临床疗效。方法研究对象选择2016年4月—2018年4月收治的80例重症肌无力患者;以抽号的方式进行分组,单号为研究组,双号为对照组,每组各40例;对照组使用甲基强的松龙进行药物治疗,观察组使用甲基强的松龙联合中剂量环磷酰胺进行药物治疗;记录分析两组服用不同药物之后的治疗效率、呼吸功能恢复情况、以及不良反应发生情况。结果记录分析两组数据得到,前8d两组治疗效率差异无统计学意义(P>0.05),第9d后研究组治疗效率明显高于对照组;研究组呼吸功能恢复情况优于对照组;研究组不良发应发生率(12.50%)低于对照组(32.50%)。结论甲基强的松龙与中剂量环磷酰胺联合治疗重症肌无力危象,能提高患者治疗效率,使患者呼吸功能恢复良好,且能减少不良发应的发生,值得推广使用。

Objective To analyze the clinical effect of methylprednisolone combined with cyclophosphamide in the treatment of myasthenia gravis crisis.Methods 80 patients with myasthenia gravis treated in the hospital from April,2016 to April,2018 were divided into study group of single number and control group of double number, with 40 cases in each group.The control group were treated with methylprednisolone,and the observation group were treated with methylprednisolone combined with middle dose cyclophosphamide.Thetherapeutic efficiency, respiratory function recovery and adverse reactions in the two groups after taking different drugs were recorded and analyzed.Results There was no significant difference in treatment efficiency between the two groups on the first 8 days(P>0.05).After 9 days, the therapeutic efficiency of the study group was significantly higher than that of the control group,and the recovery of respiratory function in the study group was better than that in the control group.The incidence of adverse hair reaction in the study group(12.50%)was lower than that in the control group(32.50%).Conclusion The combination of methylprednisolone and middle dose cyclophosphamide in the treatment of myasthenia gravis crisis can improve the treatment efficiency,restore the respiratory function of the patients,and reduce the occurrence of adverse response.So it is worth popularizing.