舍曲林联合小剂量富马酸喹硫平治疗老年抑郁症效果分析

Effects of Sertraline combined with low-dose Quetiapine fumarate in treatment of senile depression

目的:本文评估舍曲林联合小剂量富马酸喹硫平治疗老年抑郁症的临床疗效及安全性。方法:选取老年抑郁症患者64例,按随机数字表法分组,其中研究组(32例)给予舍曲林联合小剂量富马酸喹硫平治疗,对照组(32例)仅给予舍曲林抗抑郁治疗,总疗程为12周。疗程结束后利用汉密尔顿抑郁量表(HAMD)评定疗效,观察不良反应发生率。结果:治疗后,研究组的总有效率(87.5%),明显高于对照组(65.6%),差异有统计学意义(P<0.05);研究组的不良反应发生率为25.0%,明显高于对照组的18.7%,差异无统计学意义(P>0.05)。结论:舍曲林联合小剂量富马酸喹硫平治疗老年抑郁症疗效比单用舍曲林疗效更显著。

Objective:To investigate clinical efficacy and safety of Sertraline combined with low-dose Quetiapine fumarate in treatment of senile depression.Methods:64 patients with senile depression were enrolled and divided into study group and control group according to the random number table method.The study group (32 patients) received Sertraline combined with low-dose Quetiapine fumarate,while the control group (32 patients) received only Sertraline.The total course of treatment was 12 weeks.After the end of the course of treatment,the Hamilton depression scale (HAMD) was used to evaluate the effects,and the incidence of adverse reactions was observed.Results:After the treatment,the total effective rate of the observation group (87.5%) was significantly higher than that of the control group (65.6%),and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the study group was 25.0%,which was significantly higher than 18.7% of the control group,and the difference was statistically significant (P<0.05).Conclusions:Sertraline combined with low-dose Quetiapine fumarate in the treatment of senile depression is more effective than Sertraline alone.