低能量超脉冲CO2点阵激光在眼周年轻化治疗中的临床应用

Clinical application of ultra-pulsed fractional CO2 laser with lower energy in treatment of periocular rejuvenation

目的:对比30例患者采用低能量超脉冲CO2点阵激光治疗前后眼周皱纹及眼睑松弛的等级评分,分析低能量超脉冲CO2点阵激光在眼周年轻化包括改善眼周皱纹和眼睑松弛中的应用效果。方法:选择符合标准的30例眼周皱纹和眼睑松弛患者,采用超脉冲CO2点阵激光治疗,使用DeepFX手具、能量5 mJ、重复频率600 Hz、10 mm光斑扫描一次,皱纹走行区域用2 mm光斑、相同能量重复治疗1次,由2名资深皮肤科医师依据眼睑松弛量化表在首次治疗前及治疗后7 d、1个月、3个月和6个月进行评分,并进行统计学分析。结果:与治疗前比较,治疗后7 d时患者眼睑松弛量化表评分差异无统计学意义(P>0.05),治疗后1个月时患者眼睑松弛量化表评分明显降低(P<0.05),且治疗后3~6个月时患者眼睑松弛量化表评分进一步降低(P<0.01),效果更明显。本组30例患者治疗后通常会有一过性红斑、肿胀和轻度灼痛,均能耐受,无严重并发症发生。结论: 5 mJ 低能量超脉冲CO2点阵激光治疗眼周皱纹和眼睑松弛有效,安全性高,无严重不良反应发生。

Objective: To compare the scores of periocular wrinkle and blepharochalasis of the patients before and after the treatment of ultra-pulsed fractional CO2 laser with low energy,and to illuminate the efficacy of ultra-pulsed fractional CO2 laser with lower energy in eyelid rejuvenation including periocular wrinkle and blepharochalasis.Methods: Thirty patients with periocular wrinkles and blepharochalasis who met the inclusion criteria were selected.The patients were treated with ultra-pulsed fractional CO2 laser;the laser parameters were 10 mm spot size,pulse energy 5 mJ and repetition rate 600 Hz and the wrinkle walking areas were treated with 2 mm spot size and the same energy again.Two senior dermatologists scored according to the eyelid laxity scale before treatment and 7 d,1 month ,3 months and 6 months after treatment,and statistical analysis was performed.Results: Compared with before treatment,there was no significant difference in the scores of eyelid laxity scale 7 d after treatment(P >0.05);the score of eyelid laxity scale was significantly decreased 1 month after treatment (P <0.05);the scores of eyelid laxity scale were significantly decreased 3-6 months after treatment (P <0.01),and the curative effect was more obvious.In this group of 30 patients,there were usually transient erythema,swelling and mild burning pain after treatment.But no serious complications occurred.Conclusion: Ultra-pulsed fractional CO2 laser with lower energy(5 mJ) can improve the periocular wrinkles and blepharochalasis effectively with high security and without severe side effects.