早发冠心病患者血清补体C3、C4水平与LDL-C的相关性分析

Correlation Analysis between Serum Complement C3,C4 Levels and LDL-C in Patients with Premature Coronary Artery Disease

【目的】研究早发冠心病人群血清补体C3、C4及低密度脂蛋白胆固醇(LDL-C)水平并分析补体C3、C4与LDL-C在早发冠心病人群中的相关性。【方法】收集2018年1月至2018年9月于茂名市人民医院心血管内科住院经冠状动脉造影明确诊断为冠心病的患者共255例,分为早发冠心病组108例,晚发冠心病组147例;另收集健康体检者组100例为对照组。各项生化指标采用茂名市人民医院检验科全自动生化检测仪检验的结果。【结果】早发冠心病组、晚发冠心病组、健康体检者组的补体C3、C4及LDL-C水平比较,差异具有统计学意义(P<0.05)。早发冠心病组中补体C3、C4与LDL-C呈正相关(P<0.05);晚发冠心病组和健康体检者组中,补体C3、C4与LDL-C无明显相关(P>0.05)。【结论】早发冠心病患者补体C3、C4水平与LDL-C呈正相关。

【Objective】The aim of this study was to investigate the associations between serum complement C3,C4 and low density lipoprotein cholesterol(LDL-C)levels and early-onset coronary heart disease.【Methods】We enrolled 255 cases of coronary angiography confirmed coronary artery disease from January 2018 to September 2018.All the patients were divided into early-onset coronary heart disease group(108 cases)and late-onset coronary heart disease group(147 cases).Besides,100 healthy subjects were enrolled and used as controls.Serum levels of C3,C4 and LDL-C were analyzed by automatic biochemical analyzer.【Results】Levels of serum C3,C4 and LDL-C in early-onset coronary heart disease group,late-onset coronary heart disease group and healthy control group were significantly different (P < 0.05).In early-onset coronary heart disease group,C3 and C4 were positively correlated with LDL-C(P < 0.05). However,there was no significant correlation(P > 0.05)between C3,C4 and LDL-C in late-onset coronary heart disease group and healthy control group.【Conclusions】The levels of C3 and C4 were positively correlated with LDL-C only in the early-onset coronary heart disease patients.