奥氮平治疗急性期精神病的临床效果

Clinical effect of olanzapine in the treatment of patients with acute psychosis

目的:探讨奥氮平在精神科疾病治疗过程中的临床疗效。方法:抽取本院于2017年2月~2018年12月收治的96例精神科康复治疗患者,随机分为治疗A组与治疗B组,分别采用奥氮平和氯氮平治疗,比较治疗干预后各时间点(72h及1、2、3周)的不良反应症状量表(TESS)评分、临床疗效总评量表(CGI)评分以及精神病评定量表(BPRS)评分。结果:在治疗干预后,在72h及1、2、3周时,治疗A组的TESS、CGI、BPRS评分均较治疗B组明显改善(P<0.05)。结论:精神科疾病治疗中,与氯氮平治疗相比,给予奥氮平治疗干预,对TESS评分、CGI评分以及BPRS评分的改善程度较为显著,值得临床推广。

Objective:To explore the clinical effect of olanzapine in the rehabilitation treatment of psychiatric diseases. Methods:A total of 96 psychiatric rehabilitation patients admitted from February 2017 to December 2018 in our hospital were randomly divided into treatment A group and treatment B group. Clozapine was given to the patients in the treatment B group and olanzapine was given to the patients in the treatment A group. The scores of adverse reaction symptom scale(TESS),clinical curative effect scale(CGI) and psychiatric rating scale(BPRS)were compared between the two groups at 72 h,2 weeks and 3 weeks after treatment. Results:The TESS score,CGI score and BPRS score of the patients in the treatment A group at 72 hours,1,2 and 3 weeks after treatment were significantly higher than those in the treatment B group(P<0.05). Conclusion:Compared with clozapine,olanzapine can significantly improve the TESS score,CGI score and BPRS score in the rehabilitation treatment of psychiatric patients,and the effect of olanzapine is faster than that of clozapine. Therefore,olanzapine is worth popularizing in rehabilitation therapy for psychiatric diseases.