孟鲁司特钠治疗小儿喘息性支气管炎的临床疗效及不良反应分析

Clinical efficacy and adverse reactions of montelukast sodium in the treatment of asthmatic bronchitis in children

目的:分析研讨孟鲁司特钠治疗小儿喘息性支气管炎的临床疗效及不良反应。方法:随机从我院2016年5月~2018年6月收治的小儿喘息性支气管炎患者中抽取80例进行讨论,用随机数字法分组,40例接受常规治疗(对照组),另40例接受常规治疗联合孟鲁司特钠治疗(研究组),观察比较两组治疗效果和安全性。结果:研究组总疗效高于对照组,数据差异较大(P<0.05)。研究组症状改善时间、住院时间低于对照组,数据差异较大(P<0.05)。研究组共发生1例心悸、1例头痛,对照组未发生明显不良反应,组间数据无较大差异(P>0.05)。结论:小儿喘息性支气管炎采用孟鲁司特钠药物治疗,可显著提升疗效,改善气道高反应性,预防病情发展,改善生活质量。

Objective:To analyze the clinical efficacy and adverse reactions of montelukast sodium in the treatment of asthmatic bronchitis in children. Methods:80 case of children with asthmatic bronchitis admitted to our hospital from May 2016 to June 2018 were randomly selected for discussion. They were randomly divided into two groups:40 cases received routine treatment(control group)and 40 cases received routine treatment combined with montelukast sodium treatment(study group). The therapeutic effect and safety of the two groups were observed and compared.Result:The total curative effect of the study group was 95% higher than that of the control group(60%),and the difference was significant(P<0.05). The improvement time of symptoms and hospitalization time in the study group were lower than those in the control group,and the data were significantly different(P<0.05). There were 1 case of palpitation and 1 case of headache in the study group. There was no significant adverse event in the control group,and there was no significant difference between the two groups(P >0.05).Conclusion:The use of montelukast sodium in the treatment of asthmatic bronchitis in children can significantly improve the curative effect,improve the airway hyperresponsiveness,prevent the development of the disease and improve the quality of life.