观察埃索美拉唑联合莫沙必利治疗反流性食管炎的疗效

Observation on efficacy of esomeprazole combined with mosapride on the treatment of reflux esophagitis

目的观察分析埃索美拉唑联合莫沙必利治疗反流性食管炎的临床疗效。方法385例反流性食管炎患者作为研究对象,按照随机原则分为治疗组(193例)和对照组(192例)。治疗组患者采用埃索美拉唑联合莫沙必利进行治疗,对照组患者采用奥美拉唑联合莫沙必利进行治疗。观察比较两组患者临床疗效、食管炎愈合情况及不良反应发生情况。结果经治疗后,治疗组患者总有效率为96.89%(187/193),明显高于对照组的84.90%(163/192),差异有统计学意义(χ2=16.758,P=0.000<0.05)。治疗后,胃镜检查下治疗组患者食管炎愈合总有效率为97.41%(188/193),明显高于对照组的84.38%(162/192),差异有统计学意义(χ2=19.786, P=0.000<0.05)。在治疗期间,治疗组患者的不良反应发生率为6.22%,明显低于对照组的14.06%,差异有统计学意义(χ2=6.507, P=0.011<0.05)。结论对于反流性食管炎患者采用埃索美拉唑联合莫沙必利治疗能够显著提高临床疗效及食管炎愈合率,且安全可靠,不良反应较少,值得临床推广应用。

Objective To observe and analyze the clinical efficacy of esomeprazole combined with mosapride on the treatment of reflux esophagitis. Methods A total of 385 reflux esophagitis patients as study subjects were randomly divided into treatment group(193 cases) and control group(192 cases). The treatment group was treated with esomeprazole combined with mosapride, and the control group was treated with omeprazole combined with mosapride. The clinical efficacy, healing status of esophagitis and occurrence of adverse reactions in two groups was observed and compared. Results After treatment, the treatment group had obviously higher total effective rate as 96.89%(187/193) than 84.90%(163/192) in the control group, and the difference was statistically significant(χ2=16.758, P=0.000<0.05). After treatment, the treatment group had obviously higher total effective rate of esophagitis healing as 97.41%(188/193) than 84.38%(162/192) in the control group, and the difference was statistically significant(χ2=19.786, P=0.000<0.05). During treatment, the treatment group had obviously lower incidence of adverse reactions as 6.22% than 14.06% in the control group, and the difference was statistically significant(χ2=6.507, P=0.011<0.05). Conclusion Esomeprazole combined with mosapride can significantly improve the clinical efficacy of patients with reflux esophagitis and healing rate of esophagitis with less adverse reactions and it is safe and reliable. It is worthy of clinical promotion and application.