丙种球蛋白冲击治疗在儿科高热患儿中的应用效果分析

Effect analysis of γ globulin shock therapy in children with high fever in Department of Pediatrics

目的探讨丙种球蛋白冲击治疗在儿科高热患儿中的应用效果。方法60例持续高热患儿,随机分为丙球组和对照组,每组30例。对照组患儿给予传统退烧、抗病毒和补液等对症支持治疗,丙球组患儿在对照组基础上给予持续丙种球蛋白冲击治疗。观察比较两组患儿的退热时间、痊愈时间、住院时间及药物不良反应发生情况。结果丙球组患儿的退热时间、痊愈时间及住院时间分别为(4.11±0.65)、(5.96±1.66)、(9.61±1.20)d,均明显短于对照组的(6.74±1.02)、(11.99±1.52)、(12.30±1.41)d,差异均有统计学意义(P<0.05)。丙球组患儿仅出现1例过敏反应,对照组患儿未发生任何药物不良反应。两组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论在常规治疗基础上辅助应用丙种球蛋白冲击治疗儿科高热患儿有助于缩短其病程,加速退热,促进疾病的尽快康复。

Objective To discuss the application effect of γ globulin shock therapy in children with high fever in department of pediatrics. Methods A total of 60 children with persistent high fever were randomly divided into γ globulin group and control group, with 30 cases in each group. The control group received symptomatic supportive treatment of traditional fever abatement, antiviral therapy and fluid replacement, and γ globulin group received continuous γ globulin shock therapy on the basis of the control group. Observation and comparison were made on fever abatement time, recovery time, hospitalization time, and occurrence of adverse drug reactions between the two groups. Results γ globulin group had obviously shorter fever abatement time, recovery time and hospitalization time respectively as(4.11±0.65),(5.96±1.66) and(9.61±1.20) d than(6.74±1.02),(11.99±1.52) and(12.30±1.41) d in control group, and their difference was statistically significant(P<0.05).γ globulin group had 1 case of allergic reactions, and the control group had no case of allergic reactions. There was no statistically significant difference in incidence of adverse drug reactions between the two groups(P>0.05). Conclusion Adjuvant application of γ globulin impulse therapy based on children with high fever in department of pediatrics can shorten the course of disease, accelerate fever abatement, and promote the recovery of the disease as soon as possible.