西式饮食与炎症性肠病相关性的研究进展

Research Progress on Relationship Between Western Diet and Inflammatory Bowel Disease

炎症性肠病(IBD)包括溃疡性结肠炎和克罗恩病,是一种病因不明的慢性复发性消化道炎性病变。近年IBD发病率呈逐年递增的态势,流行病学显示IBD的发生与西式饮食存在一定关联。西式饮食可能通过破坏菌群结构、损伤黏膜屏障、激发黏膜固有免疫反应等方式增加IBD的易感性。本文就西式饮食与IBD发病率、发病机制的关系以及IBD的饮食干预作一综述。

Inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn’s disease (CD), is a gastroenterological tract inflammatory disease with unknown etiology. In recent years, the morbidity of IBD is gradually increased. Epidemiological survey has indicated that IBD is associated with Western diet. Western diet increases IBD susceptibility via affecting the composition of intestinal microflora, injuring intestinal barrier and activating the inherent immunity. This article reviewed the relationship between Western diet and the incidence rate and pathogenesis of IBD, and the diet intervention of IBD.