摘要
反复植入失败(RIF)是目前生殖医学领域的主要难题之一。良好的子宫内膜容受性减少了RIF发生的可能性。研究发现RIF和子宫内膜容受性与免疫、非编码RNA、粘附因子等因素相关。通过维持免疫平衡,探索RIF患者相关基因多态性,发现粘附因子和非编码RNA等生物标志物,进而提供了RIF的潜在治疗方法。
Repeated implantation failure(RIF)is a major problem faced by clinicians and researchers.Good endometrial receptivity reduces the likelihood of RIF occurrence.Studies have found that RIF and endometrial receptivity are related to immunity,non-coding RNA,adhesion factors etc.By maintaining the immune balance,exploring the polymorphism of related genes in patients with RIF,finding biomarkers such as adhesion factors and non-coding RNA,it provides a potential therapy for RIF.
作者
牛凯迪
王春雪
于月新
NIU Kai-di;WANG Chun-xue;YU Yue-xi(Reproduction Medicine Center,Heping Campus of General Hospital of Northern Theater Command,Shenyang 110003)
出处
《生殖医学杂志》
CAS
2019年第8期961-964,共4页
Journal of Reproductive Medicine
关键词
反复植入失败
子宫内膜容受性
免疫细胞
生物标志物
基因多态性
Repeated implantation failure
Endometrial receptivity
Immunological cell
Biomarkers
Gene polymorphism
