摘要
目的探讨脊柱骨质疏松性椎体压缩骨折(OVCF)椎体成形术后患者卧床时间与再骨折的关系。方法将200例OVCF椎体成形术后患者(OVCF组)依据术后1年是否再骨折分为再骨折组(n=50)和无再骨折组(n=150)。记录两组卧床时间。同期选取非OVCF志愿者50例(非OVCF组)作为对照。检测所有研究对象骨转换指标[Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、Ⅰ型前胶原N端前肽(P1NP)]、椎体骨密度(BMD),分析卧床时间与再骨折的关系。结果OVCF组β-CTX明显高于非OVCF组,OVCF组P1NP、椎体BMD明显低于非OVCF组,差异均有统计学意义(P<0.001)。再骨折组术后卧床时间、β-CTX明显高于无再骨折组,P1NP、椎体BMD明显低于无再骨折组,差异均有统计学意义(P<0.001)。Pearson相关性分析结果显示,卧床时间与β-CTX呈正相关(P<0.001),与P1NP、椎体BMD呈负相关(P<0.001)。结论OVCF椎体成形术后患者卧床时间与再骨折的发生有关,卧床时间长可能会引起骨转换紊乱而导致BMD下降,从而引起再骨折的发生。
Objective To investigate the relationship between the bed rest time and the re-fracture after percutaneous vertebroplasty for spinal osteoporotic vertebral compression fracture(OVCF).Methods The 200 patients after vertebroplasty with OVCF(OVCF group)were divided into re-fracture group(n=50)and non-fracture group(n=150)according to whether they had re-fracture at 1 year after operation,the bed time was recorded in two groups.At the same time,50 non-OVCF volunteers(non-OVCF group)were selected as controls.The bone conversion index[typeⅠcollagen carboxyl end peptide beta special sequence(beta-CTX),typeⅠprocollagen N endpeptide(P1NP)],vertebral bone mineral density(BMD)were detected in all subjects,the relationship between bed time and re-fracture were analyzed.Results Theβ-CTX in OVCF group was significantly higher than that in non-OVCF group,P1NP and vertebral BMD in OVCF group were significantly lower than those in non-OVCF group,the differences were statistically significant(P<0.001).The bed rest time andβ-CTX of re-fracture group were significantly higher than those in the non-fracture group,the P1NP and vertebral BMD in the re-fracture group were significantly lower than those in the non-fracture group,the differences were statistically significant(P<0.001).Pearson correlation analysis showed that the bed time was positively correlated withβ-CTX(P<0.001),and it was negatively correlated with P1NP and vertebral BMD(P<0.001).Conclusions The bed time of patients with OVCF after percutaneous vertebroplasty is related to the occurrence of re-fracture,the long time in the bed may cause the disorder of bone transformation,and lead to the decrease of BMD,which causes the occurrence of re-fracture.
作者
吴廷瑞
郝定均
WU Ting-rui;HAO Ding-jun(Graduate School,Xi′an Medical College,Xi′an,Shaanxi710021,China;Dept of Spinal Surgery,Hong Hui Hospital Affiliated to Medical College of Xi′an Jiaotong University,Xi′an,Shaanxi710054,China)
出处
《临床骨科杂志》
2019年第4期393-396,共4页
Journal of Clinical Orthopaedics
基金
国家自然科学基金资助项目(编号:81472098)