血清胃蛋白酶原在早期胃癌中的诊断价值

Diagnostic value of serum pepsinogen in early gastric cancer

胃癌是消化系统疾病中最常见的恶性肿瘤之一,其具有隐匿性、发病率高、恶性度高、早期诊断难、患者预后差、生存期短等特点。但其病因及发病机制尚不明确,目前认为是遗传和环境因素共同作用的结果,且诊断胃癌的金标准仍是反复多次胃镜检查联合病理活检,因此,早期诊断对于胃癌患者的预后至关重要。新研究发现血清胃蛋白酶原的检测对早期胃癌具有诊断作用。本文就检测血清胃蛋白酶原基础上联合其他方式对早期胃癌诊断价值的研究进展进行综述。

Gastric cancer is one of the most common malignantcies in digestive system diseases.It is characterized by dormant,high incidence,high malignant degree,difficult to make early diagnosis,poor prognosis and short survival period.However,its etiology and pathogenesis are still unclear.It is currently considered to be the result of a combination of genetic and environmental factors,and the current gold standard for the diagnosis of gastric cancer is still repeated multiple gastroscopy combined with pathological biopsy.Therefore,early diagnosis of gastric cancer is essential for prognosis of patients.New studies have found that serum pepsinogen detection of early gastric cancer has a diagnostic role.This article reviews the research progress on the diagnostic value of early gastric cancer based on the detection of serum pepsinogen combined with other methods.