伴中央颞区棘波的良性儿童癫癎静息态功能磁共振成像度中心度研究

A resting-state fMRI study on degree centrality of benign epilepsy of childhood with centro-temporal spikes

目的采用度中心度(DC)法探讨伴中央颞区棘波的良性儿童癫癎(BECTS)患儿神经功能网络连接变化。方法选择2010年1月至2017年12月确诊的27例BECTS患儿作为观察对象,并以年龄、性别与之相匹配的正常儿童作为正常对照。受试者于静息态接受fMRI扫描,DC法进行数据处理,采用Pearson相关分析评价DC差异脑区与Raven标准推理测验(RSPM)智商和视听整合连续执行测验(IVA-CPT)结果的相关性。结果与正常对照组相比,BECTS组患儿DC值增加的脑区包括右侧额上回和右侧后扣带回,DC值降低脑区为双侧小脑后叶、双侧纹状体和(或)丘脑皮质下团块和右侧额上回;DC值增加的右侧后扣带回分别与RSPM测验智商(r=-0.597,P=0.001)和综合注意力商(r=-0.400,P=0.039)呈负相关,而RSPM测验智商则与DC值降低的左侧小脑后叶(r=0.442,P=0.021)和右侧纹状体和(或)丘脑(r=0.452,P=0.018)呈正相关。结论 BECTS与丘脑-皮质网络功能异常有关,DC法为BECTS患儿样放电的神经生物学机制研究提供了一种新的方法。

Objective To investigate the functional connectivity changes of benign epilepsy of childhood with centrotemporal spikes(BECTS)by using degree centrality(DC)analysis.Methods Choose 27 children diagnosed as BECTS from January 2010 to December 2017 as object of observation and 27 age/sex-matched normal children as control.All subjects were performed fMRI in resting state.DC analysis was used to characterize the connectome patterns of whole-brain functional networks.Pearson correlation analysis was performed to evaluate the relationship between DC values of brain regions that differed between BECTS and normal children and the behavioral factors,including Raven’s Standard Progressive Matrices(RSPM)intelligence quotient(IQ)and Integrated Visual and Auditory Continuous Performance Test(IVA-CPT).Results Compared with normal children,BECTS children exhibited higher DC values in the right superior frontal gyrus and right posterior cingulate gyrus,and lower DC values in the bilateral cerebellar posterior lobes,subcortical mass in bilateral corpus striatum and/or thalami and right superior frontal gyrus.The higher DC value in the right posterior cingulate gyrus showed significant negative correlations with RSPM IQ score(r=-0.597,P=0.001)and full scale attention quotient score(r=-0.400,P =0.039).The RSPM IQ score showed significant positive correlations with the lower DC values in left cerebellar posterior lobe(r = 0.442,P = 0.021)and right corpus striatum/thalamus(r = 0.452,P = 0.018).Conclusions BECTS is associated with functional abnormalities in thalamic-cortical networks.DC.analysis could provide a brand-new method for exploring the neurobiological mechanisms of epileptic discharges in BECTS.