安胎汤结合黄体酮、依诺肝素钠在复发性流产孕早期治疗中的应用

Application of Antai Decoction Combined with Progesterone and Enoxaparin Sodium in Early Pregnancy Treatment of Recurrent Spontaneous Abortion

目的:研究安胎汤结合黄体酮、依诺肝素钠在复发性流产(RSA)孕早期治疗中的应用。方法:将120例RSA孕早期患者随机均分为两组,其中对照组给予黄体酮和依诺肝素钠进行治疗,观察组在此基础上加用安胎汤,两组均以7天为1个疗程,治疗至妊娠满12周,比较两组患者症状、有效率、妊娠成功率、血清β-人绒毛膜促性腺激素(β-HCG)和孕酮(P)水平以及分娩结局。结果:观察组和对照组治疗有效率分别为96.67%和85.00%,两组临床疗效差异有统计学意义(P<0.05);治疗后,两组主症阴道出血、下腹坠痛、腰膝酸软,次症头晕耳鸣、夜尿频数、面色无华、畏寒肢冷及证候积分均明显降低(P<0.05),且观察组各症状积分低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清β-HCG和P水平均明显升高(P<0.05),两组P水平差异有统计学意义(P<0.05);观察组最终妊娠成功率、分娩时孕周高于对照组,剖宫产率低于对照组,差异有统计学意义(P<0.05)。结论:安胎汤结合黄体酮、依诺肝素钠用于RSA孕早期治疗可有效提高患者血清孕酮水平,改善临床症状,提升治疗效果,同时维持正常妊娠,保证胎儿正常发育,提高妊娠成功率。

Objective:To study the application of Antai Decoction combined with Progesterone and Enoxaparin Sodium in the early pregnancy treatment of recurrent spontaneous abortion(RSA). Methods:120 cases of RSA patients with early pregnancy were randomly and evenly divided into two groups. The controlled group was given Progesterone and Enoxaparin Sodium,and the observation group was treated with Antai Decoction,and 7 d was taken as a course of treatment,and they were treated until 12 w of gestation. The symptoms,effective rate,pregnancy success rate,levels of serum β-human chorionic gonadotropin(β-HCG) and progesterone(P),and delivery outcomes were compared between the two groups. Results:The effective rates of the observation group and the controlled group were 96.67% and 85.00% respectively,and the difference in clinical efficacy between the two groups was statistically significant(P<0.05). After treatment,the scores of main symptoms of vaginal bleeding,lower abdominal pain,soreness and weakness of waist and knees,and secondary symptoms of dizziness and tinnitus,nocturia,lusterless complexion and extreme chilliness were all significantly reduced in the two groups(P<0.05),and the symptoms scores in the observation group were lower than those in the controlled group(P<0.05). After treatment,the levels of serum β-HCG and P were increased significantly in the two groups(P<0.05),and there was a statistically significant difference in P level between the two groups(P<0.05). The final gestational success rate and gestational age at delivery in the observation group were higher than those in the controlled group while the cesarean section rate was lower than that in the controlled group(P<0.05). Conclusions:Antai Decoction combined with Progesterone and Enoxaparin Sodium in early pregnancy treatment of RSA can not only effectively improve serum progesterone level,promote clinical symptoms,and improve treatment effects,but also can maintain normal pregnancy,and ensure normal development of fetus and improve the pregnancy success rate.