炎症性肠病脑功能变化研究进展

Advances in the study of brain function changes in inflammatory bowel disease

炎症性肠病(IBD)是慢性非特异性肠道炎症性疾病,其病因尚未明确。既往研究表明,IBD患者常伴有焦虑、抑郁,这可能与脑结构和功能受损及肠道菌群变化相关,因此,脑-肠-肠道菌群轴在IBD的发生与发展起着重要作用。血氧水平依赖性功能磁共振,能够客观、精确地定位具有特殊反映的脑功能区,为探索IBD患者脑功能的变化及其发病机制带来帮助。文章将基于脑-肠-肠道菌轴,对IBD脑功能变化的现状及前景进行综述。

Inflammatory bowel disease(IBD) is a chronic non-specific inflammatory disorder that commonly affects gastrointestinal tract. The cause is not clear. Previous studies have shown that IBD patients often suffer from anxiety and depression, which may be associated with impaired brain structure and function and changes in gut microbiome. Based on these findings, many researches indicate brain-gut-microbiome axis may play an important role in the occurrence and development of IBD. Blood oxygenation level dependent functional magnetic resonance (BOLD-fMRI) can detect brain function area with special response accurately and objectively, which helps to investigate the changes of brain function and its pathogenesis in IBD patients. This article reviews the current status and future prospects in IBD brain function changes based on the brain-gut-microbiome axis.