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血小板/淋巴细胞计数比值对2型糖尿病患者发生糖尿病视网膜病变的诊断价值研究 被引量:6

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摘要 目的分析血小板/淋巴细胞计数比值(PLR)对2型糖尿病患者发生糖尿病视网膜病变的诊断价值。方法95例2型糖尿病患者,依据是否患有糖尿病视网膜病变分为观察组(48例)和对照组(47例)。观察组为糖尿病视网膜病变患者,对照组为非糖尿病视网膜病变患者。对两组患者的白细胞计数、血小板计数、淋巴细胞计数、血小板/淋巴细胞计数比值、血肌酐、尿素氮、空腹血糖、糖化血红蛋白、总胆固醇等生化指标进行检测并行单因素分析,将有统计学意义的因素进行多因素Logistic回归分析。结果两组患者白细胞计数、血肌酐、尿素氮、空腹血糖、糖化血红蛋白、总胆固醇水平比较,差异无统计学意义(P>0.05)。观察组患者血小板计数的(225.42±13.31)×10^9/L、血小板/淋巴细胞计数比值(133.89±16.32)均显著高于对照组的(191.24±12.52)×10^9/L、(62.34±13.67),淋巴细胞计数(1.86±0.35)×10^9/L显著低于对照组的(2.24±0.41)×10^9/L,差异有统计学意义(P<0.05)。单因素分析显示,血小板计数、淋巴细胞计数及血小板/淋巴细胞计数比值均为糖尿病视网膜病变相关影响因素(P<0.05)。多因素Logistic回归分析显示,血小板/淋巴细胞计数比值为糖尿病视网膜病变的独立危险因素[B=1.124;SE=0.665;Wald-χ^2=3.967;P=0.017;EXP=3.157;95%CI=(1.542,7.642)]。结论血小板/淋巴细胞计数比值对糖尿病视网膜病变的发生有临床诊断价值,可作为2型糖尿病随访指标。
出处 《中国实用医药》 2019年第20期77-78,共2页 China Practical Medicine
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