真菌中PKS-NRPS杂合天然产物研究进展

Research progress on fungal PKS-NRPS hybrid metabolites

真菌聚酮合酶-非核糖体多肽合成酶(PKS-NRPS)由于聚合两大主要催化模块PKS与NRPS,能够催化结合来源广泛的聚酮骨架和氨基酸生成结构丰富多样和生物活性广泛的天然产物.本文对2013年至2019年4月真菌来源的14个PKS-NRPS基因及其对应的72个PKS-NRPS杂合天然产物的化学结构、生物活性及生物合成进行总结和论述,并对目前为止报道的所有26个PKS-NRPS基因的同源性及与化合物结构之间的相关性进行分析和讨论,为真菌PKS-NRPS类天然产物及其生物合成研究提供参考.

Fungal polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) consists of two major types of catalytic modules, PKS and NRPS, which are capable of combining a wide range of polyketone backbones and amino acids to yield complex compounds with diverse structures and impressive biological activities. This review summarizes 14 PKS-NRPS genes and 72 corresponding metabolites reported from fungi from 2013 to April 2019. The biological activities and the biosynthesis of these compounds were also included. The relationship between the homology of 26 PKS-NRPS genes reported so far and the chemical structures of the corresponding metabolites were explored and discussed. This review may provide reference for further research on the PKS-NRPS hybrid genes and their products in fungi.