探讨原发性高血压患者血浆sST2浓度与左心功能的关系

The relationship between soluble ST2 concentration and diastolic heart failure in essential hypertension patients

目的:探讨原发性高血压(EH)患者血浆sST2浓度与舒张性心力衰竭(DHF)的关系。方法:采用横断面调查研究,选择2017-06-2017-12在新乡市中心医院就诊的EH患者76例为研究对象,并分为EH组(40例)与DHF组(EH合并DHF,36例)。记录左室质量指数、血浆sST2浓度和N末端脑钠肽前体(NT-proBNP)浓度。结果:DHF组患者左室质量指数、sST2浓度和NT-proBNP浓度均明显高于EH组(均P<0.05)。sST2预测EH患者发生DHF的ROC曲线下面积为0.81(95%CI:0.68~0.87),高于NT-proBNP的曲线下面积0.74(95%CI:0.59~0.83)。Logistic回归分析显示,sST2浓度和NT-proBNP浓度是EH患者发生DHF的独立预测因素。结论:sST2浓度和NT-proBNP浓度对EH患者发生DHF具有良好的辅助诊断价值。

Objective:To investigate the relationship between soluble ST2 concentration and diastolic heart failure(DHF)in essential hypertension(EH)patients.Method:This was a hospital-based single-center cross-sectional study.A total of 76 cases with EH in Xinxiang Central Hospital from June 2017 to December 2017 were randomly divided into EH group(n=40)and DHF group(with EH andDHF,n=36).Left ventricular mass index,NT-proBNP and soluble ST2 concentrations were recorded.Result:Left ventricular mass index,NT-proBNP and soluble ST2 concentration were higher in DHF group than those in EH group(all P<0.05).The area under the receiver operating characteristic curve(AUC)of soluble ST2 predicting DHF in EH patients was 0.81(95%CI:0.68-0.87),which was higher than that of NT-proBNP(AUC:0.74,95%CI:0.59-0.83).Logistic regression analysis showed that NT-proBNP and soluble ST2 concentration were independent predictors of DHF in EH patients.Conclusion:Plasma soluble ST2 and NT-proBNP concentrations are good predictorsfor DHF in EH patients.