静脉滴注胺碘酮治疗急性心肌梗死合并房颤患者的疗效和不良反应观察

Observation on the efficacy and side effects of intravenous amiodarone in the treatment of 120 patients with acute myocardial infarction complicated with atrial fibrillation

目的:探讨胺碘酮静脉滴注治疗急性心肌梗死合并心房颤动的疗效和不良反应。方法:收治急性心肌梗死合并心房颤动患者120例,分为两组各60例。参照组采用西地兰治疗,治疗组则静脉滴注胺碘酮。观察两组临床效果和不良反应情况。结果:治疗组房颤总转复率、房颤转复后30d内窦性心律维持总有效率均高于参照组,差异有统计学意义(P<0.05)。治疗组用药后1h、2h、24h心室率及不良反应发生率均低于参照组,差异有统计学意义(P<0.05)。结论:胺碘酮治疗急性心肌梗死合并心房颤动可促进患者恢复窦性心律,提高房颤控制率,且用药不良反应少,安全性高,可作为临床控制病情的理想药物。

Objective:To investigate the efficacy and side effects of intravenous amiodarone in the treatment of acute myocardial infarction complicated with atrial fibrillation.Methods:120 patients with acute myocardial infarction complicated with atrial fibrillation were selected.They were divided into the two groups with 60 cases in each group.The reference group was treated with cedilan.The treatment group was given intravenous amiodarone and the clinical effects and side effects of the two groups were observed.Results:The total recovery rate of atrial fibrillation and the total effective rate of sinus rhythm maintenance within 30 days after atrial fibrillation conversion in the treatment group were higher than those in the control group,the difference was statistically significant(P<0.05).The ventricular rate in the treatment group was lower than that in the control group at 1 h,2 h and 24 h after treatment,the difference was statistically significant(P<0.05).The incidence of adverse reactions in treatment group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:Amine iodine ketone therapy for acute myocardial infarction combined with atrial fibrillation can promote the recovery of sinus rhythm,improve the control rate of atrial fibrillation,and has fewer adverse drug reactions and high safety.It can be used as an ideal drug for clinical control of the disease.