中药注射液不良反应213例分析

Analysis of 213 cases of adverse drug reactions of traditional Chinese medicine injection

目的分析医院中药注射液不良反应(ADR)发生的规律及特点,为临床合理安全用药提供参考.方法收集医院2013年1月-2017年12月上报的中药注射液ADR报告213例,回顾性分析患者基本情况、给药途径、药物种类、临床表现、反应分级及转归情况.结果 213例报告中发生ADR的男性患者略多于女性,其中年龄>60岁的患者最多(23.95%);静脉给药是引发ADR的全部给药途径;单个品种注射用血栓通引起的ADR最多(18.78%);以皮肤及其附件损害最为常见(68.32%).结论中药注射液ADR与多个因素相关,应提高临床工作者对中药注射液ADR的认识,确保患者用药安全.

Objective To investigate the characteristics and regularity of adverse drug reaction( ADR) of traditional Chinese medicine injection in the hospital and provide reference for the clinical rational drug use. Methods Totally 213 ADR reports in the hospital from January 2013 to December 2017 were collected,retrospectively analysis was performed according to the patient's fundamental states,route of administration,drug categories,clinical manifestations,reaction grading and regres- sion. Results 213 cases of ADR reports,the number of males was slightly higher than that of females;those aged over 60 were in the majority( 23. 95%);One hundred percent of ADR were related to intravenous infusion;Xueshuantong injection caused the highest proportion of ADR( 18. 78%);The major organs involved in ADR were skin structure( 68. 32%). Conclusion ADR of traditional Chinese medicine injection is related to a variety of factors,ADR monitoring should be strengthened and en- sure patient medication safety.