生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的疗效观察

Efficacy observation of somatostatin combined with pantoprazole in treatment of cirrhosis with upper gastrointestinal hemorrhage

目的观察生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的临床疗效.方法选择医院2015年1月-2018年7月收治的肝硬化合并上消化道出血患者42例,按照随机数字表法分为观察组和对照组各21例.对照组患者采用生长抑素治疗,观察组采用生长抑素联合泮托拉唑治疗.比较2组患者的临床疗效、止血时间、输血量、住院时间及不良反应发生情况.结果治疗后观察组患者临床总有效率明显高于对照组,止血时间、住院时间均明显短于对照组,输血量明显少于对照组,差异均有统计学意义(P<0.05).2组治疗期间不良反应发生率比较差异无统计学意义(P>0.05).结论生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血能更有效地缩短患者止血时间及住院时间、降低患者输血量,且安全性高,疗效较好,临床应用价值高.

Objective To observe the efficacy of somatostatin combined with pantoprazole in treatment of cirrhosis with upper gastrointestinal hemorrhage. Methods Selected 42 patients with cirrhosis and upper gastrointestinal bleeding,ad- mitted to the hospital from January 2015 to July 2018. According to the random number table method,they were divided into observation group and control group,each of 21 cases. Control group was treated with somatostatin,and observation group was treated with somatostatin and pantoprazole. The clinical efficacy,hemostasis time,blood transfusion,hospitalization time and ad- verse reactions were compared between two groups. Results After treatment,the total clinical effective rate of observation group was significantly higher than that of control group,the hemostasis time and hospitalization time were significantly shorter than control group,and the blood transfusion volume was significantly lower than that of control group,the difference was statis- tically significant( P < 0. 05). There was no significant difference in the incidence of adverse reactions between two groups( P > 0. 05). Conclusion The combination of somatostatin and pantoprazole is effective in treatment of cirrhosis with upper gastro- intestinal bleeding,and has high clinical value.