丙硫氧嘧啶与甲巯咪唑治疗妊娠合并甲状腺功能亢进症的疗效比较研究

Comparative effectiveness research of propylthiouracil and methimidazole for pregnancy complicated with hyperthyroidism

目的比较丙硫氧嘧啶与甲巯咪唑治疗妊娠合并甲状腺功能亢进症的临床疗效.方法选取宜宾大房医院2017年6月-2018年6月收治的妊娠合并甲状腺功能亢进症患者100例,随机分为对照组与观察组,各50例.对照组患者予以甲疏咪唑片治疗,观察组患者予以丙硫氧嘧啶片治疗.比较两组患者治疗后甲状腺功能指标[游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]、妊娠结局及新生儿出生5 min后Apgar评分与体质量.结果观察组患者FT3、FT4低于对照组,TSH高于对照组,足月产率高于对照组(P<0.05).两组患者早产率、流产率及剖宫产率比较,差异无统计学意义(P>0.05).观察组新生儿出生5 min后Apgar评分高于对照组(P<0.05).两组新生儿体质量比较,差异无统计学意义(P>0.05).结论与甲疏咪唑比较,丙硫氧嘧啶治疗妊娠合并甲状腺功能亢进症的临床疗效更优,可更有效改善患者甲状腺功能和妊娠结局.

Objective To study the comparative effectiveness research of propylthiouracil and methimidazole for pregnancy complicated with hyperthyroidism.Methods A total of 100 cases of patients with pregnancy complicated with hyperthyroidism were selected from June 2017 to June 2018 in Yibin Dafang Hospital,which were randomly divided into control group and observation group,50 cases in each group.The control group was treated with methimidazole tablets,the observation group was treated with propylthiouracil tablets.Thyroid function index(FT3,FT4,TSH) after treatment,pregnancy outcome,and Apgar score and body mass after birth 5 min were compared between the two groups.Results The observation group of FT3 and FT4 were lower than control group,TSH was higher than control group,and the full-term yield was higher than control group(P<0.05).There was no significant difference in premature delivery rate,abortion rate or cesarean section rate between the two groups(P>0.05).The Apgar score of neonates after birth 5 min in the observation group was higher than control group(P<0.05).There was no significant difference in body mass between the two groups(P>0.05).Conclusion Compared with methylimidazolium,propylthiouracil have an exact clinical effect for pregnancy complicated with hyperthyroidism,it can improve thyroid function and pregnancy outcome more effectively.